Evidence map›Paper›PMID 21772329›Full record

ArticleBritish journal of cancer2011

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies.

Endogenous Hormones and Breast Cancer Collaborative Group, T J Key, P N Appleby, G K Reeves, A W Roddam, K J Helzlsouer, A J Alberg, D E Rollison, J F Dorgan, L A Brinton and 42 more

Open access · hybridAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 6 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 6 syntheses or guidelines pooled it, 383 citations in OpenAlex.

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  5. Breast cancer and persistent organic pollutants (excluding DDT): a systematic literature review.Environmental science and pollution research international · 2016
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  13. Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy.Climacteric : the journal of the International Menopause Society · 2021
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Endogenous Hormones and Breast Cancer Collaborative GroupEndogenous Hormones and Breast Cancer Collaborative Group, Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK.
T J Key
P N Appleby
G K Reeves
A W Roddam
K J Helzlsouer
A J Alberg
D E Rollison
J F Dorgan
L A Brinton
K Overvad
R Kaaks
A Trichopoulou
F Clavel-Chapelon
S Panico
E J Duell
P H M Peeters
S Rinaldi
I S Fentiman
M Dowsett
J Manjer
P Lenner
G Hallmans
L Baglietto
D R English
G G Giles
J L Hopper
G Severi
H A Morris
S E Hankinson
S S Tworoger
K Koenig
A Zeleniuch-Jacquotte
A A Arslan
P Toniolo
R E Shore
V Krogh
A Micheli
F Berrino
E Barrett-Connor
G A Laughlin
M Kabuto
S Akiba
R G Stevens
K Neriishi
C E Land
J A Cauley
Li Yung Lui
Steven R Cummings
M J Gunter
T E Rohan
H D Strickler

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
CLINICAL/IMMUNOLOGIC/GENETIC ANALYSES OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROMEZ01AI000732 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RAO, VEMULKONDA · 1995 to 2008
$1.1M
Breast Cancer Now BREAST CANCER NOW RESEARCH CENTRECancer Research UK C570/A5028
6 · The paper itself

Abstract

backgroundBreast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood.

methodsCross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies.

resultsConcentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer.

conclusionSex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

Indexed as

AdultAgedAged, 80 and overBreast NeoplasmsCarcinomaCross-Sectional StudiesFemaleGonadal Steroid HormonesHumansMiddle AgedPostmenopausePregnancyRetrospective StudiesRisk FactorsGonadal Steroid Hormones

Identifiers

PMID21772329
PMCPMC3188939
OpenAlexW2167985837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.