Evidence map›Paper›PMID 21771956›Full record

ArticleRadiology2011

Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging.

David J Brenner, Igor Shuryak, Andrew J Einstein

Registry-linked trialAbstract read
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In one paragraph

Article in Radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01436006 (Adult and Paediatric Patient Radiation Doses From Multidetector CT Scans), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01436006 completednot on this map

Adult and Paediatric Patient Radiation Doses From Multidetector CT Scans: a National Survey

TypeobservationalSponsorUniversity of PalermoRan2011 to 2012Enrolled6,700ConditionsCancer
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  7. CT scanning and questions about benefit versus risk.Journal of applied clinical medical physics · 2025
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  17. Estimating cancer risk fromJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David J BrennerCenter for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA. djb3@columbia.edu
Igor Shuryak
Andrew J Einstein

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo quantify the effect of reduced life expectancy on cancer risk by comparing estimated lifetime risks of lung cancer attributable to radiation from commonly used computed tomographic (CT) examinations in patients with and those without cancer or cardiac disease. MATERIALS AND

methodsWith the use of clinically determined life tables, reductions in radiation-attributable lung cancer risks were estimated for coronary CT angiographic examinations in patients with multivessel coronary artery disease who underwent coronary artery bypass graft (CABG) surgery and for surveillance CT examinations in patients treated for colon cancer. Statistical uncertainties were estimated for the risk ratios in patients who underwent CABG surgery and patients with colon cancer versus the general population.

resultsPatients with decreased life expectancy had decreased radiation-associated cancer risks. For example, for a 70-year-old patient with colon cancer, the estimated reduction in lifetime radiation-associated lung cancer risk was approximately 92% for stage IV disease, versus 8% for stage 0 or I disease. For a patient who had been treated with CABG surgery, the estimated reduction in lifetime radiation-associated lung cancer risk was approximately 57% for a 55-year-old patient, versus 12% for a 75-year-old patient.

conclusionThe importance of radiation exposure in determining optimal imaging usage is much reduced for patients with markedly reduced life expectancies: Imaging justification and optimization criteria for patients with substantially reduced life expectancies should not necessarily be the same as for those with normal life expectancies.

Indexed as

Life ExpectancyHumansLung NeoplasmsNeoplasms, Radiation-InducedRiskRisk AssessmentTomography, X-Ray Computed

Identifiers

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.