ArticleProceedings of the National Academy of Sciences of the United States of America2011
Mechanosensitive shivering of model tissues under controlled aspiration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Soft matter mechanics of immune cell aggregates.Journal of the Royal Society, Interface · 2025Article
- Cartilaginous microtissues exhibit extreme resilience under compression with size-dependent mechanical properties.Biomaterials · 2025Article
- A Benzodiazepine-Derived Molecule That Interferes with the Bio-Mechanical Properties of Glioblastoma-Astrocytoma Cells Altering Their Proliferation and Migration.International journal of molecular sciences · 2025Article
- Linking Metastatic Potential and Viscoelastic Properties of Breast Cancer Spheroids via Dynamic Compression and Relaxation in Microfluidics.Advanced healthcare materials · 2025Article
- Cell spheroid viscoelasticity is deformation-dependent.Scientific reports · 2024Article
- Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids.APL bioengineering · 2024Article
- Confinement induces internal flows in adherent cell aggregates.Journal of the Royal Society, Interface · 2024Article
- Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization.Communications biology · 2024Article
- SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces.Molecular biology of the cell · 2023Article
- Response of cells and tissues to shear stress.Journal of cell science · 2023Review
- High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip.Lab on a chip · 2023Article
- Active wetting of epithelial tissues: modeling considerations.European biophysics journal : EBJ · 2023Review
- Marangoni effect and cell spreading.European biophysics journal : EBJ · 2022Review
- Mechanical waves caused by collective cell migration: generation.European biophysics journal : EBJ · 2022Review
- Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues.Biophysical reviews · 2021Review
- Multiscale nature of cell rearrangement caused by collective cell migration.European biophysics journal : EBJ · 2021Review
- Review
- Effect of liquid flow by pipetting during medium change on deformation of hiPSC aggregates.Regenerative therapy · 2019Article
- Quantitative characterization of viscoelastic fracture induced by time-dependent intratumoral pressure in a 3D model tumor.Biomicrofluidics · 2019Article
- Jamming state transition and collective cell migration.Journal of biological engineering · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During embryonic development and wound healing, the mechanical signals transmitted from cells to their neighbors induce tissue rearrangement and directional movements. It has been observed that forces exerted between cells in a developing tissue under stress are not always monotonically varying, but they can be pulsatile. Here we investigate the response of model tissues to controlled external stresses. Spherical cellular aggregates are subjected to one-dimensional stretching forces using micropipette aspiration. At large enough pressures, the aggregate flows smoothly inside the pipette. However, in a narrow range of moderate aspiration pressures, the aggregate responds by pulsed contractions or "shivering." We explain the emergence of this shivering behavior by means of a simple analytical model where the uniaxially stretched cells are represented by a string of Kelvin-Voigt elements. Beyond a deformation threshold, cells contract and pull on neighboring cells after a time delay for cell response. Such an active behavior has previously been found to cause tissue pulsation during dorsal closure of Drosophila embryo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.