ArticleBehavioural brain research2011
Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in rats.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Attenuation of cue-induced heroin-seeking by the atypical antidepressant mirtazapine.Drug and alcohol dependence reports · 2026Article
- Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference.Addiction biology · 2024Article
- Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization.Scientific reports · 2021Article
- Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.ACS chemical neuroscience · 2019Article
- Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats.Progress in neuro-psychopharmacology & biological psychiatry · 2017Article
- Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's disease.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Using conditioned place preference to identify relapse prevention medications.Neuroscience and biobehavioral reviews · 2013Review
- Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside.Pharmacology & therapeutics · 2012Review
- The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.Brain research · 2012Article
- SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats.BMC neuroscience · 2012Article
- Context-dependent effects of a single administration of mirtazapine on the expression of methamphetamine-induced conditioned place preference.Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The atypical antidepressant mirtazapine enhances monoaminergic transmission; thus, mirtazapine therapy may counter the hypo-activation of monoamine systems associated with withdrawal from methamphetamine abuse. Human addiction therapy will likely require chronic administration that is given after brain and behavioral maladaptations are established. To emulate this scenario in rats, we ascertained if acute or repeated mirtazapine treatments could antagonize previously established consequences of repeated methamphetamine. Methamphetamine-induced conditioned place preference (CPP) was used, wherein methamphetamine (1mg/kg, i.p.) was administered in a unique environmental context once-daily for three days interposed by saline injections in an alternate context. Subsequently, mirtazapine (5mg/kg, i.p.) was administered in the home cage either as 10 once-daily injections or a single injection. The expression of CPP was determined in drug-free rats three days after the last mirtazapine injection. Expression of methamphetamine-induced CPP was inhibited by 10 home cage administrations of mirtazapine but not by a single injection of mirtazapine. These findings reveal that mirtazapine can inhibit the maintenance of methamphetamine-induced CPP and that treatment duration and/or treatment timing contributes to this effect of mirtazapine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.