ArticleGenome biology2011
Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered Regions.bioRxiv : the preprint server for biology · 2026Article
- Functional and Structural Determinants of Long- and Short-Term Evolution of Herpesvirus Proteins.Molecular biology and evolution · 2025Article
- Design of intrinsically disordered protein variants with diverse structural properties.Science advances · 2024Article
- Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.Nature cell biology · 2024Article
- Design of intrinsically disordered protein variants with diverse structural properties.bioRxiv : the preprint server for biology · 2023Article
- FREEDA: An automated computational pipeline guides experimental testing of protein innovation.The Journal of cell biology · 2023Article
- Enrichment of intrinsically disordered residues in ohnologs facilitates abiotic stress resilience in Brassica rapa.Journal of plant research · 2023Article
- FREEDA: an automated computational pipeline guides experimental testing of protein innovation by detecting positive selection.bioRxiv : the preprint server for biology · 2023Article
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- Evidence for a synergistic effect of post-translational modifications and genomic composition of eEF-1α on the adaptation ofEcology and evolution · 2021Article
- Genome-Wide Characterization of theFrontiers in plant science · 2021Article
- Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells.Cancers · 2020Article
- Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.Journal of molecular evolution · 2020Article
- Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection.Virus evolution · 2020Article
- Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- New Zealand Tree and Giant Wētā (Orthoptera) Transcriptomics Reveal Divergent Selection Patterns in Metabolic Loci.Genome biology and evolution · 2019Article
- Comparative analysis of mutational robustness of the intrinsically disordered viral protein VPg and of its interactor eIF4E.PloS one · 2019Article
- Human long intrinsically disordered protein regions are frequent targets of positive selection.Genome research · 2018Article
- Pathogens and Disease Play Havoc on the Host Epiproteome-The "First Line of Response" Role for Proteomic Changes Influenced by Disorder.International journal of molecular sciences · 2018Review
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the adaptive changes that alter the function of proteins during evolution is an important question for biology and medicine. The increasing number of completely sequenced genomes from closely related organisms, as well as individuals within species, facilitates systematic detection of recent selection events by means of comparative genomics.
resultsWe have used genome-wide strain-specific single nucleotide polymorphism data from 64 strains of budding yeast (Saccharomyces cerevisiae or Saccharomyces paradoxus) to determine whether adaptive positive selection is correlated with protein regions showing propensity for different classes of structure conformation. Data from phylogenetic and population genetic analysis of 3,746 gene alignments consistently shows a significantly higher degree of positive Darwinian selection in intrinsically disordered regions of proteins compared to regions of alpha helix, beta sheet or tertiary structure. Evidence of positive selection is significantly enriched in classes of proteins whose functions and molecular mechanisms can be coupled to adaptive processes and these classes tend to have a higher average content of intrinsically unstructured protein regions.
conclusionsWe suggest that intrinsically disordered protein regions may be important for the production and maintenance of genetic variation with adaptive potential and that they may thus be of central significance for the evolvability of the organism or cell in which they occur.
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