ArticleThe European journal of neuroscience2011
The diffusional properties of dendrites depend on the density of dendritic spines.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
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- Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study.Frontiers in neuroscience · 2024Article
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- Reinforcing Interdisciplinary Collaborations to Unravel the Astrocyte "Calcium Code".Journal of molecular neuroscience : MN · 2022Review
- Influence of T-Bar on Calcium Concentration Impacting Release Probability.Frontiers in computational neuroscience · 2022Article
- Increased Signal Delays and Unaltered Synaptic Input Pattern Recognition in Layer III Neocortical Pyramidal Neurons of the rTg4510 Mouse Model of Tauopathy: A Computer Simulation Study With Passive Membrane.Frontiers in neuroscience · 2021Article
- Biophysics of Biochemical Signaling in Dendritic Spines: Implications in Synaptic Plasticity.Biophysical journal · 2017Review
- The Slow Dynamics of Intracellular Sodium Concentration Increase the Time Window of Neuronal Integration: A Simulation Study.Frontiers in computational neuroscience · 2017Article
- Purkinje cell intrinsic excitability increases after synaptic long term depression.Journal of neurophysiology · 2016Article
- Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.Scientific reports · 2016Article
- Facilitated glutamate release at Schaffer collateral to CA1 synapses has access to an exclusive population of NMDA receptors.Brain research · 2015Article
- Anomalous extracellular diffusion in rat cerebellum.Biophysical journal · 2015Article
- Anomalous diffusion inspires anatomical insights.Biophysical journal · 2015Article
- Biased diffusion in three-dimensional comb-like structures.The Journal of chemical physics · 2015Article
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- Nanoparticle assisted photothermal deformation of individual neuronal organelles and cells.Biomedical optics express · 2014Article
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4 authors at 4 institutions in 4 countries.
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Abstract
We combined computational modeling and experimental measurements to determine the influence of dendritic structure on the diffusion of intracellular chemical signals in mouse cerebellar Purkinje cells and hippocamal CA1 pyramidal cells. Modeling predicts that molecular trapping by dendritic spines causes diffusion along spiny dendrites to be anomalous and that the value of the anomalous exponent (d(w) ) is proportional to spine density in both cell types. To test these predictions we combined the local photorelease of an inert dye, rhodamine dextran, with two-photon fluorescence imaging to track diffusion along dendrites. Our results show that anomalous diffusion is present in spiny dendrites of both cell types. Further, the anomalous exponent is linearly related to the density of spines in pyramidal cells and d(w) in Purkinje cells is consistent with such a relationship. We conclude that anomalous diffusion occurs in the dendrites of multiple types of neurons. Because spine density is dynamic and depends on neuronal activity, the degree of anomalous diffusion induced by spines can dynamically regulate the movement of molecules along dendrites.
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