Evidence map›Paper›PMID 21770803›Full record

ArticleOcular immunology and inflammation2011

Diagnostic approach to ocular toxoplasmosis.

Justus G Garweg, Jolanda D F de Groot-Mijnes, Jose G Montoya

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Ocular immunology and inflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Areas of uncertainty in endophthalmitis care.World journal of clinical cases · 2026
    Review
  3. Ocular Toxoplasmosis: Advances inPathogens (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Molecular diagnosis of human toxoplasmosis: the state of the art.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Role of microRNAs in the Infection byFrontiers in cellular and infection microbiology · 2021
    Review
  13. Seronegative ocular toxoplasma panuveitis in an immunocompetent patient.American journal of ophthalmology case reports · 2020
    Article
  14. Article
  15. Review
  16. Monitoring of visual field over 6 months after active ocular toxoplasmosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Justus G GarwegSwiss Eye Institute and University of Bern, Bern, Switzerland. justus.garweg@swiss-eye-institute.com
Jolanda D F de Groot-Mijnes
Jose G Montoya
Stanford Medicine · USUniversity Medical Center Utrecht · NLUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmic retinochoroiditis is deemed a local event, which may fail to evoke a detectable systemic immune response. A correct diagnosis of the disease is a necessary basis for estimating its clinical burden. This is not so difficult in a typical clinical picture. In atypical cases, further diagnostic efforts are to be installed. Although the aqueous humor may be analyzed for specific antibodies or the presence of parasitic DNA, the DNA burden therein is low, and in rare instances a confirmation would necessitate vitreous sampling. A laboratory confirmation of the diagnosis is frustrated by individual differences in the time elapsing between clinical symptoms and activation of specific antibody production, which may result in false negatives. In congenital ocular toxoplasmosis, a delay in the onset of specific local antibody production could reflect immune tolerance. Herein, the authors attempt to provide a simple and practicable algorithm for a clinically tailored diagnostic approach in atypical instances.

Indexed as

AlgorithmsAntibodies, ProtozoanBlood-Retinal BarrierChorioretinitisClinical Laboratory TechniquesEnzyme-Linked Immunosorbent AssayEyeFalse Negative ReactionsHumansImmunity, HumoralImmunoblottingToxoplasmaToxoplasmosis, OcularAntibodies, Protozoan

Identifiers

PMID21770803
PMCPMC3154545
OpenAlexW2131421899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.