ArticleJournal of neurotrauma2011
The effect of progesterone dose on gene expression after traumatic brain injury.
Article in Journal of neurotrauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Mechanistic investigation of methadone, tolfenamic acid, and cilnidipine in traumatic brain injury: a novel multi-target perspective outcome of network pharmacology.Inflammopharmacology · 2025Article
- Critical illness and sex hormones: response and impact of the hypothalamic-pituitary-gonadal axis.Therapeutic advances in endocrinology and metabolism · 2025Review
- Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.Experimental neurology · 2020Article
- Article
- Effects of Female Sex Steroids Administration on Pathophysiologic Mechanisms in Traumatic Brain Injury.Translational stroke research · 2018Review
- Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury.Scientific reports · 2017Article
- Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury.Journal of neuroinflammation · 2016Article
- Combination Therapies for Traumatic Brain Injury: Retrospective Considerations.Journal of neurotrauma · 2016Article
- Treatment of traumatic brain injury with anti-inflammatory drugs.Experimental neurology · 2016Review
- Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model.The AAPS journal · 2015Article
- A Combination Therapy of Nicotinamide and Progesterone Improves Functional Recovery following Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- Progesterone for neuroprotection in pediatric traumatic brain injury.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2015Review
- Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials.Brain injury · 2015Review
- Comparison of the effect of minocycline and simvastatin on functional recovery and gene expression in a rat traumatic brain injury model.Journal of neurotrauma · 2014Article
- Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup.Journal of neurotrauma · 2014Review
- The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects.Acta pharmacologica Sinica · 2013Review
- Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats.Neural regeneration research · 2013Article
- Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Microarray-based transcriptional profiling was used to determine the effect of progesterone in the cortical contusion (CCI) model. Gene ontology (GO) analysis then evaluated the effect of dose on relevant biological pathways. Treatment (vehicle, progesterone 10 mg/kg or 20 mg/kg given i.p.) was started 4 h post-injury and administered every 12 h post-injury for up to 72 h, with the last injection 12 hr prior to death for the 24 h and 72 h groups. In the CCI-injured vehicle group compared to non-injured animals, expression of 1,114, 4,229, and 291 distinct genes changed >1.5-fold (p<0.05) at 24 h, 72 h, and 7 days, respectively. At 24 h, the effect of low-dose progesterone on differentially expressed genes was <20% the effect of higher dose compared to vehicle. GO analysis identified a significant effect of low- and high-dose progesterone treatment compared to vehicle on DNA damage response. At 72 h, high-dose progesterone treatment compared to vehicle affected expression of almost twice as many genes as did low-dose progesterone. Both low- and high-dose progesterone resulted in expression of genes regulating inflammatory response and apoptosis. At 7 days, there was only a modest difference in high-dose progesterone compared to vehicle, with only 14 differentially expressed genes. In contrast, low-dose progesterone resulted in 551 differentially expressed genes compared to vehicle. GO analysis identified genes for the low-dose treatment involved in positive regulation of cell proliferation, innate immune response, positive regulation of anti-apoptosis, and blood vessel remodeling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.