ArticleAnalytical chemistry2011
Head-to-head comparisons of carbon fiber microelectrode coatings for sensitive and selective neurotransmitter detection by voltammetry.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- Application of Aptamer-Carbon Surfaces for Electrochemical Label-Free Detection of Vancomycin.Biosensors · 2026Article
- Machine Learning for Neurotransmitter Monitoring by Fast Voltammetry: Current and Future Prospects.ACS chemical neuroscience · 2026Review
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Evaluation of In Vitro Serotonin-Induced Electrochemical Fouling Performance of Boron Doped Diamond Microelectrode Using Fast-Scan Cyclic Voltammetry.Biosensors · 2024Article
- Methods of Protection of Electrochemical Sensors against Biofouling in Cell Culture Applications.ACS omega · 2024Article
- Electrochemical treatment in KOH improves carbon nanomaterial performance to multiple neurochemicals.The Analyst · 2024Article
- In Vitro Biofouling Performance of Boron-Doped Diamond Microelectrodes for Serotonin Detection Using Fast-Scan Cyclic Voltammetry.Biosensors · 2023Article
- A Novel Poly(3-hexylthiophene) Engineered Interface for Electrochemical Monitoring of Ascorbic Acid During the Occurrence of Glutamate-Induced Brain Cytotoxic Edemas.Research (Washington, D.C.) · 2023Article
- Epitaxial Self-Assembly of Interfaces of 2D Metal-Organic Frameworks for Electroanalytical Detection of Neurotransmitters.ACS nano · 2022Article
- A Platinized Carbon Fiber Microelectrode-Based Oxidase Biosensor for Amperometric Monitoring of Lactate in Brain Slices.Sensors (Basel, Switzerland) · 2022Article
- Implantable aptamer-field-effect transistor neuroprobes for in vivo neurotransmitter monitoring.Science advances · 2021Article
- Electrochemical treatment in KOH renews and activates carbon fiber microelectrode surfaces.Analytical and bioanalytical chemistry · 2021Article
- Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression.Analytical and bioanalytical chemistry · 2021Article
- Article
- Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate.Biosensors · 2021Article
- Nano-engineering the material structure of preferentially oriented nano-graphitic carbon for making high-performance electrochemical micro-sensors.Scientific reports · 2020Article
- Fundamentals of fast-scan cyclic voltammetry for dopamine detection.The Analyst · 2020Review
- Nanodiamond Coating Improves the Sensitivity and Antifouling Properties of Carbon Fiber Microelectrodes.ACS sensors · 2019Article
- 3D-printed CuO nanoparticle-functionalized flow reactor enables online fluorometric monitoring of glucose.Mikrochimica acta · 2019Article
- Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection.Analytical methods : advancing methods and applications · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Voltammetry is widely used to investigate neurotransmission and other biological processes but is limited by poor chemical selectivity and fouling of commonly used carbon fiber microelectrodes (CFMs). We performed direct comparisons of three key coating materials purported to impart selectivity and fouling resistance to electrodes: Nafion, base-hydrolyzed cellulose acetate (BCA), and fibronectin. We systematically evaluated the impact on a range of electrode parameters. Fouling due to exposure to brain tissue was investigated using an approach that minimizes the use of animals while enabling evaluation of statistically significant populations of electrodes. We find that BCA is relatively fouling-resistant. Moreover, detection at BCA-coated CFMs can be tuned by altering hydrolysis times to minimize the impact on sensitivity losses while maintaining fouling resistance. Fibronectin coating is associated with moderate losses in sensitivity after coating and fouling. Nafion imparts increased sensitivity for dopamine and norepinephrine but not serotonin, as well as the anticipated selectivity for cationic neurotransmitters over anionic metabolites. Although Nafion has been suggested to resist fouling, both dip-coating and electrodeposition of Nafion are associated with substantial fouling, similar to levels observed at bare electrodes after exposure to brain tissue. Direct comparisons of these coatings identified unique electroanalytical properties of each that can be used to guide selection tailored to the goals and environment of specific studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.