ArticleBirth defects research. Part A, Clinical and molecular teratology2011
MicroRNA gene expression signatures in the developing neural tube.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Up-regulation of miR-10a-5p expression inhibits the proliferation and differentiation of neural stem cells by targetingActa biochimica et biophysica Sinica · 2024Article
- MicroRNA-322 overexpression reduces neural tube defects in diabetic pregnancies.American journal of obstetrics and gynecology · 2024Article
- Distinct H3K27me3 and H3K27ac Modifications in Neural Tube Defects Induced by Benzo[a]pyrene.Brain sciences · 2023Article
- Micronutrient imbalance and common phenotypes in neural tube defects.Genesis (New York, N.Y. : 2000) · 2021Review
- Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin.Science advances · 2021Article
- Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects.Epigenetics & chromatin · 2019Article
- Alteration of the microRNA expression profile and identification of miRNA/mRNA negative regulation pairs in neural tube defects.Acta biochimica et biophysica Sinica · 2019Article
- Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.Nature communications · 2017Article
- Determinants of orofacial clefting I: Effects of 5-Aza-2'-deoxycytidine on cellular processes and gene expression during development of the first branchial arch.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Determinants of orofacial clefting II: Effects of 5-Aza-2'-deoxycytidine on gene methylation during development of the first branchial arch.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Maternal Diabetes Alters Expression of MicroRNAs that Regulate Genes Critical for Neural Tube Development.Frontiers in molecular neuroscience · 2017Article
- miR-100 Inhibits the Growth and Migration of Burn-Denatured Fibroblasts.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress.Diabetes · 2016Article
- Induction Function of miR-126 in Survival and Proliferation in Neural Stem Cells.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- MicroRNA biomarkers for early detection of embryonic malformations in pregnancy.Journal of biomolecular research & therapeutics · 2014Article
- Ontogeny of small RNA in the regulation of mammalian brain development.BMC genomics · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurulation requires precise, spatio-temporal expression of numerous genes and coordinated interaction of signal transduction and gene regulatory networks, disruption of which may contribute to the etiology of neural tube defects (NTDs). MicroRNAs (miRNAs) are key modulators of cell and tissue differentiation. To define potential roles of miRNAs in development of the murine neural tube (NT), miRNA microarray analysis was conducted to establish expression profiles, and identify miRNA target genes and functional gene networks.
methodsThe miRNA expression profiles in murine embryonic NTs derived from gestational days 8.5, 9.0, and 9.5 were defined and compared utilizing miRXplore microarrays from Miltenyi Biotec GmbH, Bergisch Gladbach, Germany. Gene expression changes were verified by TaqMan quantitative Real-Time PCR. The clValid R package and the UPGMA (hierarchical) clustering method were utilized for cluster analysis of the microarray data. Functional associations among selected miRNAs were examined via Ingenuity Pathway Analysis.
resultsThe miRXplore chips enabled examination of 609 murine miRNAs. Expression of approximately 12% of these was detected in murine embryonic NTs. Clustering analysis revealed several developmentally regulated expression clusters among these expressed genes. Target analysis of differentially expressed miRNAs enabled identification of numerous target genes associated with cellular processes essential for normal NT development. Utilization of Ingenuity Pathway Analysis revealed interactive biologic networks which connected differentially expressed miRNAs with their target genes, and highlighted functional relationships.
conclusionsThe present study defined unique gene expression signatures of a range of miRNAs in the developing NT during the critical period of NT morphogenesis. Analysis of miRNA target genes and gene interaction pathways revealed that specific miRNAs might direct expression of numerous genes encoding proteins, which have been shown to be indispensable for normal neurulation. This study is the first to identify miRNA expression profiles and their potential regulatory networks in the developing mammalian NT.
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