ArticleArthritis and rheumatism2011
The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage.
Article in Arthritis and rheumatism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles.International journal of molecular sciences · 2024Article
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies.Frontiers in immunology · 2021Review
- Role of Immunoglobulins in Muscular Dystrophies and Inflammatory Myopathies.Frontiers in immunology · 2021Review
- Muscle-derived TRAIL negatively regulates myogenic differentiation.Experimental cell research · 2020Article
- Muscle Weakness in Myositis: MicroRNA-Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis.The Journal of pathology · 2019Article
- Serum-soluble TRAIL: a potential biomarker for disease activity in myositis patients.Clinical rheumatology · 2019Article
- Involvement of p38 Activation and Mitochondria in Death of Human Leukemia Cells Induced by an Agonistic Human Monoclonal Antibody Fab Specific to TRAIL Receptor 1.International journal of molecular sciences · 2019Article
- Risk factors and disease mechanisms in myositis.Nature reviews. Rheumatology · 2018Review
- Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis.Molecular medicine reports · 2017Article
- Causes and consequences of endoplasmic reticulum stress in rheumatic disease.Nature reviews. Rheumatology · 2017Review
- Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats.Neural regeneration research · 2014Article
- Expression of tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 in patients with polymyositis and dermatomyositis.Arthritis research & therapy · 2014Article
- Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.Arthritis and rheumatism · 2013Article
- Further considerations on in vitro skeletal muscle cell death.Muscles, ligaments and tendons journal · 2013Article
- Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness.Skeletal muscle · 2013Article
- Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.PloS one · 2013Article
- The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.Arthritis and rheumatism · 2012Article
- Endoplasmic reticulum stress in skeletal muscle homeostasis and disease.Current rheumatology reports · 2012Review
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveMultinucleated cells are relatively resistant to classic apoptosis, and the factors initiating cell death and damage in myositis are not well defined. We hypothesized that nonimmune autophagic cell death may play a role in muscle fiber damage. Recent reports indicate that TRAIL may induce both NF-κB activation and autophagic cell death in other systems. We undertook this study to investigate the role of TRAIL in cell death and pathogenesis in vitro and in vivo, using myositis muscle tissues from humans and mice.
methodsGene expression profiling was performed in myositis patient and control muscle specimens. Immunohistochemistry analysis was performed to confirm the gene array findings. We also analyzed TRAIL-induced cell death (apoptosis and autophagy) and NF-κB activation in vitro in cultured cells.
resultsTRAIL was expressed predominantly in myositis muscle fibers, but not in biopsy specimens from normal or other dystrophic-diseased muscle. Autophagy markers were up-regulated in humans with myositis and in mouse models of myositis. TRAIL expression was restricted to regenerating/atrophic areas of muscle fascicles, blood vessels, and infiltrating lymphocytes. TRAIL induced NF-κB activation and IκB degradation in cultured cells that are resistant to TRAIL-induced apoptosis but that undergo autophagic cell death.
conclusionOur data demonstrate that TRAIL is expressed in myositis muscle and may mediate both activation of NF-κB and autophagic cell death in myositis. Thus, this nonimmune pathway may be an attractive target for therapeutic intervention in myositis.
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