ArticleMammalian genome : official journal of the International Mammalian Genome Society2011
Clustered transcripts that escape X inactivation at mouse XqD.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Escape from X-chromosome inactivation: from gene discovery to regulatory mechanisms.Biochemical Society transactions · 2026Review
- Escape from X inactivation is directly modulated by Xist noncoding RNA.Nature cell biology · 2026Article
- Aging promotes reactivation of the Barr body at distal chromosome regions.Nature aging · 2025Article
- Survey of gene, lncRNA and transposon transcription patterns in four mouse organs highlights shared and organ-specific sex-biased regulation.Genome biology · 2025Article
- CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation.BMC biology · 2025Article
- Review
- Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans.Genetics · 2019Article
- When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities.Physiology & behavior · 2017Review
- Article
- Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.Journal of genetics · 2015Review
- Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.Genome biology · 2015Article
- Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome.PLoS genetics · 2015Article
- Variable escape from X-chromosome inactivation: identifying factors that tip the scales towards expression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- X chromosome regulation: diverse patterns in development, tissues and disease.Nature reviews. Genetics · 2014Review
- Chromosome imbalance as a driver of sex disparity in disease.Journal of genomics · 2014Review
- Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells.Epigenetics & chromatin · 2014Article
- The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging.Biology of sex differences · 2014Article
- Deletion of an X-inactivation boundary disrupts adjacent gene silencing.PLoS genetics · 2013Article
- Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation.Developmental cell · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
X Chromosome inactivation (XCI) silences one copy of most X-linked genes in female mammals. Notably, human and mouse differ strikingly in the number and organization of the genes that escape XCI. While on the human X Chromosome (Chr) escape genes are organized in domains, the few known genes that escape inactivation in the mouse appear to be isolated. Here we characterize the gene Cxorf26 and adjacent noncoding transcripts that map to XqD. We assess allelic expression in a nonrandomly X-inactivated cell line and directly demonstrate that 2610029G23Rik (Cxorf26) and its head-to-head neighbor (5530601H04Rik) escape X inactivation, creating a small escape domain. Both genes are robustly expressed from the inactive X Chr at approximately 50 and 30% of the expression levels of the active X, respectively. Additionally, consistent with XCI escape, the first exon of Cxorf26 is embedded within an unmethylated CpG island. To extend these results, we assayed ncRNAs adjacent to three other escape genes, Eif2s3x, Kdm5c, and Ddx3x. By allelic expression, three ncRNAs (D330035k16Rik, D930009k15Rik, and Gm16481) also escape X inactivation in the mouse, consistent with previous studies that reported female-biased expression. Altogether, these results establish that mouse escapees, like their human counterparts, can be clustered. Moreover, the fact that these ncRNAs are not found on the human X raises intriguing questions about potential regulatory roles of rapidly evolving ncRNAs in controlling escape gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.