ArticleMycopathologia2011
Identification and differential gene expression of adhesin-like wall proteins in Candida glabrata biofilms.
Article in Mycopathologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular and regulatory aspects of EPA: a Nakaseomyces glabratus epithelial adhesin.Archives of microbiology · 2026Review
- Candida glabrata: A powerhouse of resistance.PLoS pathogens · 2023Article
- FLO8 deletion leads to decreased adhesion and virulence with downregulated expression of EPA1, EPA6, and EPA7 in Candida glabrata.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Article
- Niacin Limitation PromotesPathogens (Basel, Switzerland) · 2022Article
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- A novel class of Candida glabrata cell wall proteins with β-helix fold mediates adhesion in clinical isolates.PLoS pathogens · 2021Article
- Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells.PLoS pathogens · 2021Article
- Review
- Characterization of Awp14, A Novel Cluster III Adhesin Identified in a High Biofilm-FormingFrontiers in cellular and infection microbiology · 2021Article
- Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata.Scientific reports · 2020Article
- Caspofungin Induced Cell Wall Changes ofFrontiers in cellular and infection microbiology · 2020Article
- Divergent Approaches to Virulence inInternational journal of molecular sciences · 2019Review
- Review
- A Transcriptomics Approach To Unveiling the Mechanisms ofAntimicrobial agents and chemotherapy · 2019Article
- Review
- Adhesins inJournal of fungi (Basel, Switzerland) · 2018Review
- Candida glabrata Biofilms: How Far Have We Come?Journal of fungi (Basel, Switzerland) · 2017Review
- The EPA2 adhesin encoding gene is responsive to oxidative stress in the opportunistic fungal pathogen Candida glabrata.Current genetics · 2015Article
- Candida glabrata: a review of its features and resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important initial step in biofilm development and subsequent establishment of fungal infections by the human pathogen Candida glabrata is adherence to a surface. Adherence is mediated through a large number of differentially regulated cell wall-bound adhesins. The fungus can modify the incorporation of adhesins in the cell wall allowing crucial adaptations to new environments. In this study, expression and cell wall incorporation of C. glabrata adhesins were evaluated in biofilms cultured in two different media: YPD and a semi-defined medium SdmYg. Tandem mass spectrometry of isolated C. glabrata cell walls identified 22 proteins including six adhesins: the novel adhesins Awp5 and Awp6, Epa3 and the previously identified adhesins Epa6, Awp2 and Awp4. Regulation of expression of these and other relevant adhesin genes was investigated using real-time qPCR analysis. For most adhesin genes, significant up-regulation was observed in biofilms in at least one of the culturing media. However, this was not the case for EPA6 and AWP2, which is consistent with their gene products already being abundantly present in planktonic cultures grown in YPD medium. Furthermore, most of the adhesin genes tested also show medium-dependent differential regulation. These results underline the idea that many adhesins in C. glabrata are involved in biofilm formation and that their expression is tightly regulated and dependent on environmental conditions and growth phase. This may contribute to its potential to form resilient biofilms and cause infection in various host tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.