ArticleVirchows Archiv : an international journal of pathology2011
Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease.
Article in Virchows Archiv : an international journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Sasa veitchii extract on intestinal epithelial cells and gut microbiota.Journal of natural medicines · 2026Article
- Intestinal stem cell niche: An upcoming area of immense importance in gastrointestinal disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Infection and inflammation stimulate expansion of a CD74The EMBO journal · 2023Article
- Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.International journal of molecular sciences · 2019Article
- Review
- Paneth cells in intestinal physiology and pathophysiology.World journal of gastrointestinal pathophysiology · 2017Review
- Celiac Disease: Role of the Epithelial Barrier.Cellular and molecular gastroenterology and hepatology · 2017Review
- Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease.Journal of translational medicine · 2015Article
- Intestinal stem cells and celiac disease.World journal of stem cells · 2014Review
- The Natural Antimicrobial Enzyme Lysozyme is Up-Regulated in Gastrointestinal Inflammatory Conditions.Pathogens (Basel, Switzerland) · 2014Review
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Lysozyme is as an innate enzyme with potent antibacterial properties found in Paneth cells in normal duodenal crypts. Since celiac disease concurs with an abnormal duodenal microbiota we explored the expression of lysozyme in this disease. Fifty-three duodenal biopsies were stained with anti-lysozyme: 15 had normal duodenal mucosa (NDM), 7 chronic active duodenitis (CAD), 3 borderline (BL), 17 subtotal villous atrophy (SVA) and 11 total villous atrophy (TVA). NDM showed lysozyme-positive Paneth cells arranged in "Indian file" in 93.3%. In contrast, lysozyme-positive mucus metaplasia in crypts (LPMMC) replacing Paneth cells was found in 71.5% in CAD, in 96.4% in SVA/TVA, and in 2 cases with B. In 19.3% cases with BL/SVA/TVA, LPMMC replaced all Paneth cells in all crypts in entire sections. In crypts and villi, lysozyme-positive goblet cells (LPGC) were found in 92.8%. Changes were more frequent in the duodenal bulb than in pars descendens. In normal duodenal mucosa, absorptive enterocytes and goblet cells migrate from stem cells upwards, while Paneth cells migrate downwards, towards the base of the crypts. In celiac disease stem cells seem to have been re-programmed, as the normal production of Paneth cells in the crypts was replaced by lysozyme-producing mucus cells. LPMMC and LPGC in celiac disease might mirror an antimicrobial adaptation of stem cells to signals generated by pathogenic duodenal bacteria. The molecular mechanism(s) behind the abrogation of Paneth cells in duodenal crypts and its substitution by LPMMC in celiac disease remains to be elucidated.
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