Evidence map›Paper›PMID 21769128›Full record

ReviewNature reviews. Rheumatology2011

Fibromyalgia: from pathophysiology to therapy.

Tobias Schmidt-Wilcke, Daniel J Clauw

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 109 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02384603 nacompletednot on this mapstarted 2015, after this paper: background citation

Effects of Two Physiotherapeutic Treatments in Pain and Posture of Fibromyalgia Patients: Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2015 to 2018Enrolled40ConditionsFibromyalgiaArmsGlobal postural reeducation, Segmental muscle stretching exercises, Cognitive behavioral therapy
NCT03944889 early_phase1completednot on this mapstarted 2019, after this paper: background citation

Quantitative Response of Healthy Muscle Following the Induction of Capsaicin

TypeinterventionalSponsorToronto Rehabilitation InstituteRan2019 to 2020Enrolled20ConditionsCentral SensitisationArmsCapsaicin, Delsys Trigno Galileo System, Cadwell Sierra Wave, Sonosite Ultrasound Machine, Goniometer
NCT06226376 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effects of EXOPULSE Mollii Suit on Fibromyalgia Syndrome in Patients With Fibromyalgia (EXOFIB 2): A Sham Controlled Randomized Double-Blind Trial

TypeinterventionalSponsorSheikh Shakhbout Medical CityRan2024 to 2025Enrolled28ConditionsFibromyalgia, Rheumatic Diseases, Muscular Diseases, Neuromuscular DiseasesArmsEXOPULSE Mollii Suit Stimulation
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Meta-analysis of cognitive performance in fibromyalgia.Journal of clinical and experimental neuropsychology · 2018
    Pooled it
  8. Aerobic exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2017
    Pooled it
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  10. Aquatic exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2014
    Pooled it
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tobias Schmidt-WilckeChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, 48106, USA. tobiass@ med.umich.edu
Daniel J Clauw

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with fibromyalgia generally experience chronic widespread pain, which can be accompanied by further symptoms including fatigue, sleep disturbances, cognitive dysfunction, anxiety and depressive episodes. As the recognition and diagnosis of fibromyalgia has improved, the availability of therapeutic options for patients has increased. Furthermore, research into the neurobiological mechanisms that contribute to the chronic pain and concomitant symptoms experienced by patients with fibromyalgia has advanced our understanding of this debilitating disorder. In this Review, we aim to provide an overview of existing pathophysiological concepts. The roles of biological and psychological stress, genetic factors, and pain and sensory processing in the pathophysiology of fibromyalgia and related conditions are discussed. In addition, pharmacological treatments, including monoamine modulators, calcium channel modulators and γ-aminobutyric acid modulators, as well as nonpharmacological treatment options are considered.

Indexed as

FibromyalgiaStress, PhysiologicalStress, PsychologicalComplementary TherapiesDrug TherapyHumansPainRisk Factors

Identifiers

PMID21769128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.