ArticleNature chemical biology2011
Chemistry and biology of reactive oxygen species in signaling or stress responses.
Article in Nature chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 550 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
550 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Coenzyme QNutrients · 2022Pooled it
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- Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026Article
- Association of stress hyperglycemia ratio on right ventricular dysfunction and biventricular coupling in patients with acute coronary syndrome assessed by CMR feature tracking: a cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Ultrasound technology for edible mushrooms: A review of postharvest changes, applications and prospects.Food chemistry: X · 2026Review
- Water-Soluble Squaraine-Based NIR Chromofluorogenic Probe for HClO/ClOChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Intrinsic Antioxidant Capacity of Fish Muscle as Potential Link Between Pre-Harvest Biology andAntioxidants (Basel, Switzerland) · 2026Review
- Ageing alters cysteine oxidation-regulated redox signalling in skeletal muscle: Integrative omics and AI-based structural predictions.Experimental physiology · 2026Article
- Spatiotemporal analysis of reactive oxygen species using specific activity-based sensing fluorescent imaging probes.Nature reviews. Chemistry · 2026Review
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Bidirectional reactant flux coupling in hollow hierarchical covalent organic framework enabling efficient uranium extraction from seawater.Nature communications · 2026Article
- Comparative Evaluation of Antioxidant Potential in Natural Plants, In Vitro Regenerants, and Callus Cultures ofAntioxidants (Basel, Switzerland) · 2026Article
- The Chemical Structures, Neuroprotective Effects, Structure-Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review.Food science & nutrition · 2026Review
- A Nonanuclear Pd-Based Coordination Cage Featuring Ni-Chelated Porphyrin Ligand for Cancer Therapy via Combination of Chemodynamic and Photodynamic Modalities.Molecules (Basel, Switzerland) · 2026Article
- Long noncoding RNAs at the crossroads of smoking, oxidative stress, inflammation, and lung disease.Archives of toxicology · 2026Review
- Tower-shaped super-adhesive microneedles loaded with vitamin A-containing Bletilla striata vesicles: temporally regulated Inflammation resolution and ECM remodeling for scarless wound healing.Journal of nanobiotechnology · 2026Article
- Multifunctional Cu-doped MnMaterials today. Bio · 2026Article
- Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi-Targeting Therapeutic Strategy by Tannic Acid-Modified CuInPExploration (Beijing, China) · 2026Article
490 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Reactive oxygen species (ROS) are a family of molecules that are continuously generated, transformed and consumed in all living organisms as a consequence of aerobic life. The traditional view of these reactive oxygen metabolites is one of oxidative stress and damage that leads to decline of tissue and organ systems in aging and disease. However, emerging data show that ROS produced in certain situations can also contribute to physiology and increased fitness. This Perspective provides a focused discussion on what factors lead ROS molecules to become signal and/or stress agents, highlighting how increasing knowledge of the underlying chemistry of ROS can lead to advances in understanding their disparate contributions to biology. An important facet of this emerging area at the chemistry-biology interface is the development of new tools to study these small molecules and their reactivity in complex biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.