ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Effects of long-term cranberry supplementation on endocrine pancreas in aging rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health.Antioxidants (Basel, Switzerland) · 2021Review
- Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications.Nutrients · 2020Review
- Effects of cranberry extracts on gene expression in THP-1 cells.Food science & nutrition · 2017Article
- Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan.Nutrients · 2014Article
- Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent.Experimental gerontology · 2014Article
- Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice.Nutrition research and practice · 2013Article
- The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1.Age (Dordrecht, Netherlands) · 2013Article
- Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE (Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The effects of long-term cranberry consumption on age-related changes in endocrine pancreas are not fully understood. Here we treated male Fischer 344 rats with either 2% whole cranberry powder supplemented or normal rodent chow from 6 to 22 month old. Both groups displayed an age-related decline in basal plasma insulin concentrations, but this age-related decline was delayed by cranberry. Cranberry supplementation led to increased β-cell glucose responsiveness during the oral glucose tolerance test. Portal insulin concentration was 7.6-fold higher in rats fed cranberry, coupled with improved β-cell function. However, insulin resistance values were similar in both groups. Total β-cell mass and expression of pancreatic and duodenal homeobox 1 and insulin within islets were significantly enhanced in rats fed cranberry relative to controls. Furthermore, cranberry increased insulin release of an insulin-producing β-cell line, revealing its insulinotropic effect. These findings suggest that cranberry is of particular benefit to β-cell function in normal aging rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.