ArticleProceedings of the National Academy of Sciences of the United States of America2011
Increase developmental plasticity of human keratinocytes with gene suppression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
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- Relapse pathway of glioblastoma revealed by single-cell molecular analysis.Carcinogenesis · 2018Article
- Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2.Stem cells translational medicine · 2017Article
- Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient.Stem cell research · 2016Article
- Tissue elasticity regulated tumor gene expression: implication for diagnostic biomarkers of primitive neuroectodermal tumor.PloS one · 2015Article
- Training stem cells for treatment of malignant brain tumors.World journal of stem cells · 2014Review
- Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor.Cancer cell international · 2014Article
- Investigating evolutionary perspective of carcinogenesis with single-cell transcriptome analysis.Chinese journal of cancer · 2013Article
- The cellular memory disc of reprogrammed cells.Stem cell reviews and reports · 2013Review
- Cultivating stem cells for treating amyotrophic lateral sclerosis.World journal of stem cells · 2012Article
- Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall.Cancer cell international · 2012Article
- Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Review
- Control dominating subclones for managing cancer progression and posttreatment recurrence by subclonal switchboard signal: implication for new therapies.Stem cells and development · 2012Review
- Phenotype characterization of embryoid body structures generated by a crystal comet effect tail in an intercellular cancer collision scenario.Cancer management and research · 2012Article
- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies.World journal of stem cells · 2011Article
- Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes.Biotechnology advancesReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Recent evidence indicates that p53 suppression increased the efficiency of induced pluripotent stem cell (iPSC) generation. This occurred even with the enforced expression of as few as two canonical transcription factors, Oct4 and Sox2. In this study, primary human keratinocytes were successfully induced into a stage of plasticity by transient inactivation of p53, without enforced expression of any of the transcription factors previously used in iPSC generation. These cells were later redifferentiated into neural lineages. The gene suppression plastic cells were morphologically indistinguishable from human ES cells. Gene suppression plastic cells were alkaline phosphatase-positive, had normal karyotypes, and expressed p53. Together with the accumulating evidence of similarities and overlapping mechanisms between iPSC generation and cancer formation, this finding sheds light on the emerging picture of p53 sitting at the crossroads between two intricate cellular potentials: stem cell vs. cancer cell generation. This finding further supports the crucial role played by p53 in cellular reprogramming and suggests an alternative method to switch the lineage identity of human cells. This reported method offers the potential for directed lineage switching with the goal of generating autologous cell populations for novel clinical applications for neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.