ArticleProceedings of the National Academy of Sciences of the United States of America2011
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 173 citations in OpenAlex.
- Methylphenidate during early consolidation affects long-term associative memory retrieval depending on baseline catecholamines.Psychopharmacology · 2017Trial
- Impairment of novelty-dependent hippocampal behavioural tagging in Septin5-deficient mice.Molecular brain · 2026Article
- Beyond boundaries: extended temporal flexibility in synaptic tagging and capture.Communications biology · 2025Article
- Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.PloS one · 2025Article
- Multiplexed detection of nuclear immediate early gene expression reveals hippocampal neuronal subpopulations that engage in the acquisition and updating of spatial experience.Frontiers in integrative neuroscience · 2025Article
- Linking new information to a short-lasting memory trace induces consolidation in the hippocampus.iScience · 2024Article
- Sex and the facilitation of cued fear by prior contextual fear conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Arc and BDNF mediated effects of hippocampal astrocytic glutamate uptake blockade on spatial memory stages.Communications biology · 2024Article
- Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change.Communications biology · 2023Article
- Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.Molecular brain · 2023Article
- Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms.Scientific reports · 2023Article
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Environment Enrichment Facilitates Long-Term Memory Consolidation through Behavioral Tagging.eNeuro · 2023Article
- Editorial: Updates on memory modulation in health and disease.Frontiers in behavioral neuroscience · 2023Article
- Tag and capture: how salient experiences target and rescue nearby events in memory.Trends in cognitive sciences · 2022Review
- Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2.PLoS computational biology · 2022Article
- Behavioral Tagging: Role of Neurotransmitter Receptor Systems in Novel Object Recognition Long-Term Memory.ACS omega · 2022Article
- Survival of the salient: Aversive learning rescues otherwise forgettable memories via neural reactivation and post-encoding hippocampal connectivity.Neurobiology of learning and memory · 2022Article
- Disrupting reconsolidation by PKA inhibitor in BLA reduces heroin-seeking behavior.Frontiers in cellular neuroscience · 2022Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca(2+)/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.