ArticleProceedings of the National Academy of Sciences of the United States of America2011
Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Capsaicin Inhibits Multiple Voltage-Gated Ion Channels in Rabbit Ventricular Cardiomyocytes in TRPV1-Independent Manner.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature.Frontiers in physiology · 2022Article
- Article
- Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine's membrane adsorption and ion pore formation potency.Saudi journal of biological sciences · 2021Article
- The Antimicrobial Peptide Gramicidin S Enhances Membrane Adsorption and Ion Pore Formation Potency of Chemotherapy Drugs in Lipid Bilayers.Membranes · 2021Article
- Roles of Membrane Domains in Integrin-Mediated Cell Adhesion.International journal of molecular sciences · 2020Review
- Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness.Biophysical journal · 2019Article
- Time-resolved measurements of an ion channel conformational change driven by a membrane phase transition.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Gramicidin A Channel Formation Induces Local Lipid Redistribution II: A 3D Continuum Elastic Model.Biophysical journal · 2017Article
- Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism.Scientific reports · 2017Article
- A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics.The Journal of general physiology · 2015Article
- Phenomenology and energetics of diffusion across cell phase states.Saudi journal of biological sciences · 2015Article
- Ether- versus ester-linked phospholipid bilayers containing either linear or branched apolar chains.Biophysical journal · 2014Article
- A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors.Nature chemical biology · 2013Article
- Phosphoinositides alter lipid bilayer properties.The Journal of general physiology · 2013Article
- Directional interactions and cooperativity between mechanosensitive membrane proteins.Europhysics letters · 2013Article
- Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation.Faraday discussions · 2013Article
- Connection between oligomeric state and gating characteristics of mechanosensitive ion channels.PLoS computational biology · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Linear rate-equilibrium (RE) relations, also known as linear free energy relations, are widely observed in chemical reactions, including protein folding, enzymatic catalysis, and channel gating. Despite the widespread occurrence of linear RE relations, the principles underlying the linear relation between changes in activation and equilibrium energy in macromolecular reactions remain enigmatic. When examining amphiphile regulation of gramicidin channel gating in lipid bilayers, we noted that the gating process could be described by a linear RE relation with a simple geometric interpretation. This description is possible because the gating process provides a well-understood reaction, in which structural changes in a bilayer-embedded model protein can be studied at the single-molecule level. It is thus possible to obtain quantitative information about the energetics of the reaction transition state and its position on a spatial coordinate. It turns out that the linear RE relation for the gramicidin monomer-dimer reaction can be understood, and the quantitative relation between changes in activation energy and equilibrium energy can be interpreted, by considering the effects of amphiphiles on the changes in bilayer elastic energy associated with channel gating. We are not aware that a similar simple mechanistic explanation of a linear RE relation has been provided for a chemical reaction in a macromolecule. RE relations generally should be useful for examining how amphiphile-induced changes in bilayer properties modulate membrane protein folding and function, and for distinguishing between direct (e.g., due to binding) and indirect (bilayer-mediated) effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.