ReviewSeminars in cutaneous medicine and surgery2011
Pruritus: management algorithms and experimental therapies.
Review in Seminars in cutaneous medicine and surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- European S2k Guideline on Chronic PruritusActa dermato-venereologica · 2025Guideline
- Pharmacological interventions for pruritus in adult palliative care patients.The Cochrane database of systematic reviews · 2023Pooled it
- Pharmacological interventions for pruritus in adult palliative care patients.The Cochrane database of systematic reviews · 2016Pooled it
- Beyond CKD-Associated Pruritus: Paraneoplastic Itch Revealing CLL/SLL in ESRD: A Case Report.The American journal of case reports · 2025Article
- Incidence and influential factors of postoperative pruritus in morphine-based intravenous patient-controlled analgesia.Journal of the Chinese Medical Association : JCMA · 2025Article
- Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care.Plants (Basel, Switzerland) · 2024Review
- Atopic Dermatitis: Managing the Itch.Advances in experimental medicine and biology · 2024Article
- Ileal Bile Acid Transporter Blockers for Cholestatic Liver Disease in Pediatric Patients with Alagille Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Article
- The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds.Pharmacological reports : PR · 2022Review
- Review
- Gabapentinoids for Pruritus in Older Adults: A Narrative Review.Dermatology and therapy · 2021Review
- Clinical Characteristics of Itch in Renal Transplant Recipients.Frontiers in medicine · 2020Article
- Altered expression of itch‑related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch.International journal of molecular medicine · 2019Article
- Pruritus Associated with Commonly Prescribed Medications in a Tertiary Care Center.Medicines (Basel, Switzerland) · 2019Article
- Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.The Journal of allergy and clinical immunology · 2017Article
- Five-year malignancy incidence in patients with chronic pruritus: a population-based cohort study aimed at limiting unnecessary screening practices.Journal of the American Academy of Dermatology · 2014Article
- Sensory neurons and circuits mediating itch.Nature reviews. Neuroscience · 2014Review
- New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?Pflugers Archiv : European journal of physiology · 2013Review
- Neural processing of itch.Neuroscience · 2013Review
- TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.The Journal of clinical investigation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pruritus (itch) is a major symptom in many dermatologic as well as systemic diseases and has a dramatic impact on the quality of life in these patients. The symptom of itch has to be treated on the basis of its pathophysiology and its underlying disease. In daily practice, a "quick" diagnosis of the underlying disease is often difficult, although a rapid relief of the itch is desired. We often treat patients on the basis of the symptomatology. A rational therapeutic ladder for a symptomatic therapy is useful until the final diagnosis has been confirmed. There are probably many subtypes of pruritus, just as there are many diseases that cause itch. The pathophysiology in many subtypes of pruritus is still poorly understood, hindering a rapid and targeted treatment strategy. An extensive diagnostic workup is often required to determine the final cause(s) of the itch. Thus, in daily life, physicians often start with a more or less rational therapeutic strategy to combat the debilitating itch. We present possible therapeutic ladders that form the basis for effective therapeutic itch strategies in various diseases. On the basis of our current knowledge about the different pathophysiologies of itch, on clinical trials or case reports, and our own clinical experience, we aim to present therapeutic ladders for the rapid as well as long-term management of itch. Finally, we summarize current exciting developments of experimental strategies in itch research and in clinical development for itch therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.