ArticleNeurotoxicology2011
Biomarkers of organophosphorus (OP) exposures in humans.
Article in Neurotoxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Ligand binding Pro-miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase.Protein science : a publication of the Protein Society · 2025Article
- Investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry.medRxiv : the preprint server for health sciences · 2025Article
- Synthetic organic chemicals (flame retardants and pesticides) with neurotoxic potential induced behavioral impairment on zebrafish (Danio rerio): a non-invasive approach for neurotoxicology.Environmental science and pollution research international · 2021Article
- Occupational use of agrochemicals results in inhibited cholinesterase activity and altered reproductive hormone levels in male farmers from Buea, Cameroon.Toxicology research · 2021Article
- Quantitation of ortho-cresyl phosphate adducts to butyrylcholinesterase in human serum by immunomagnetic-UHPLC-MS/MS.Journal of mass spectrometry : JMS · 2015Article
- Preparation and characterization of diethoxy- and monoethoxy phosphylated ('aged') serine haptens and use in the production of monoclonal antibodies.Chemico-biological interactions · 2014Article
- Aircraft engine exhaust emissions and other airport-related contributions to ambient air pollution: A review.Atmospheric environment (Oxford, England : 1994) · 2014Review
- Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome.Analytical biochemistry · 2014Article
- Analysis of biomarker utility using a PBPK/PD model for carbaryl.Frontiers in pharmacology · 2014Article
- Review
- Polyclonal antibody to soman-tyrosine.Chemical research in toxicology · 2013Article
- Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants.Chemico-biological interactions · 2013Article
- Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures.Chemico-biological interactions · 2013Article
- Immunodetection of serum albumin adducts as biomarkers for organophosphorus exposure.The Journal of pharmacology and experimental therapeutics · 2013Article
- Advances in toxicology and medical treatment of chemical warfare nerve agents.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
- Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry.Analytica chimica acta · 2012Article
- Exposure to triaryl phosphates: metabolism and biomarkers of exposure.Journal of biological physics and chemistry : JBPC · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
There are ongoing events where aircraft engine lubricant containing tricresyl phosphates (TCPs) contaminates aircraft cabins. Some individuals have experienced tremors or other neurological symptoms that may last for many months following exposures. Mass spectrometric (MS) protocols are being developed to determine the percentage of "biomarker proteins" that are modified by such exposures, specifically on active site serines. Both plasma butyrylcholinesterase (BChE) and red cell acylpeptide hydrolase (APH) are readily inhibited by 2-(ortho-cresyl)-4H-1,3,2-benzodioxaphosphoran-2-one (CBDP) or phenyl saligenin cyclic phosphate (PSP) and have the potential to provide information about the level of exposure of an individual. We have developed immunomagnetic bead-based single-step purification protocols for both BChE and APH and have characterized the active site serine adducts of BChE by MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.