ArticleBiophysical journal2011
Modeling of supramolecular centrosymmetry effect on sarcomeric SHG intensity pattern of skeletal muscles.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Generalized 3D quasi-phase-matching model of image contrast in second harmonic generation microscopy of fibrillar collagen architectures.JPhys photonics · 2026Article
- Determination of the source of SHG verniers in zebrafish skeletal muscle.Scientific reports · 2015Article
- Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.Oxidative medicine and cellular longevity · 2015Article
- Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy.Biomedical optics express · 2014Article
- Theoretical and experimental SHG angular intensity patterns from healthy and proteolysed muscles.Biophysical journal · 2013Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A theoretical far-field second harmonic generation (SHG) imaging radiation pattern is calculated for muscular myosin taking into account both Gouy effect and light diffraction under high focusing excitation. Theoretical analysis, in agreement with experimental results obtained on healthy Xenopus muscles, shows that the increase on intensity at the middle of the sarcomeric SHG intensity pattern is generated by an off-axis constructive interference related to the specific antipolar distribution of myosin molecules within the sarcomere. The best fit of the experimental sarcomeric SHG intensity pattern was obtained with an estimated size of antiparallel, intrathick filaments' packing-width of 115 ± 25 nm localized at the M-band. During proteolysis, experimental sarcomeric SHG intensity pattern exhibits decrease on intensity at the center of the sarcomere. An effective intra- and interthick filaments centrosymmetry of 320 ± 25 nm, in agreement with ultrastructural disorganization observed at the electron microscopy level, was necessary to fit the experimental sarcomeric SHG intensity pattern. Our results show that sarcomeric SHG intensity pattern is very sensitive to misalignment of thick filaments and highlights the potential usefulness of SHG microscopy to diagnose proteolysis-induced muscular disorders.
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Registered trials
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