ArticleBiophysical journal2011
Steps and bumps: precision extraction of discrete states of molecular machines.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
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- Zero-mode waveguides visualize the first steps during gelsolin-mediated actin filament formation.Biophysical journal · 2022Article
- Mass-sensitive particle tracking to elucidate the membrane-associated MinDE reaction cycle.Nature methods · 2021Article
- Photonic-plasmonic hybrid single-molecule nanosensor measures the effect of fluorescent labels on DNA-protein dynamics.Science advances · 2017Article
- Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels.Frontiers in neuroinformatics · 2017Article
- Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.Nature cell biology · 2016Article
- An information-based approach to change-point analysis with applications to biophysics and cell biology.Biophysical journal · 2015Article
- Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides.Journal of the Royal Society, Interface · 2014Article
- Article
- Novel methods for analysing bacterial tracks reveal persistence in Rhodobacter sphaeroides.PLoS computational biology · 2013Article
- Signal processing for molecular and cellular biological physics: an emerging field.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2013Article
- Flagellar hook flexibility is essential for bundle formation in swimming Escherichia coli cells.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We report statistical time-series analysis tools providing improvements in the rapid, precision extraction of discrete state dynamics from time traces of experimental observations of molecular machines. By building physical knowledge and statistical innovations into analysis tools, we provide techniques for estimating discrete state transitions buried in highly correlated molecular noise. We demonstrate the effectiveness of our approach on simulated and real examples of steplike rotation of the bacterial flagellar motor and the F1-ATPase enzyme. We show that our method can clearly identify molecular steps, periodicities and cascaded processes that are too weak for existing algorithms to detect, and can do so much faster than existing algorithms. Our techniques represent a step in the direction toward automated analysis of high-sample-rate, molecular-machine dynamics. Modular, open-source software that implements these techniques is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.