ArticleBiophysical journal2011
Negative feedback from integrins to cadherins: a micromechanical study.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.eLife · 2021Article
- Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion.Tissue engineering. Part C, Methods · 2019Review
- The Effect of Cortical Elasticity and Active Tension on Cell Adhesion Mechanics.Biophysical journal · 2019Article
- Cell-cell and cell-extracellular matrix adhesions cooperate to organize actomyosin networks and maintain force transmission during dorsal closure.Molecular biology of the cell · 2017Article
- Horizontal alignment of 5' -> 3' intergene distance segment tropy with respect to the gene as the conserved basis for DNA transcription.Future science OA · 2017Article
- E-cadherin-mediated force transduction signals regulate global cell mechanics.Journal of cell science · 2016Article
- Regulation of epithelial cell organization by tuning cell-substrate adhesion.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Integration of cell-cell and cell-ECM adhesion in vertebrate morphogenesis.Current opinion in cell biology · 2015Review
- Cell and tissue mechanics in cell migration.Experimental cell research · 2013Review
- Micro- and nanoscale engineering of cell signaling.Annual review of biomedical engineering · 2013Review
- Cadherins in collective cell migration of mesenchymal cells.Current opinion in cell biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coupling between cell-cell and cell-matrix adhesion systems is known to affect the stability of the adhesive status of cells, as well as tissue cohesion. In this work, we perform quantitative assays of integrin-cadherin cross talk in controlled and reproducible conditions. This is achieved by plating cells on microprinted fibronectin patterns of different sizes, and simulating the formation of an intercellular contact with a microbead coated with E-cadherin extracellular domains and brought to the cell membrane. Using an optical trap, we measure the average rigidity modulus of the E-cadherin bead-cell contact as a function of the contact incubation time and of the cell spreading area. For a given incubation time, this rigidity modulus decreases by three orders of magnitude as the cell-matrix contact area, A, increases from 100 to 700 μm(2). In a similar way, the dynamics of formation of the bead-cell contact gets slower as this area increases. This is clear evidence for a strong negative feedback from cell-fibronectin onto cell-cell adhesive contacts, for which we discuss some possible mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.