ArticleBiophysical journal2011
Multivalent binding of nanocarrier to endothelial cells under shear flow.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
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- Machine learning enabled multiscale model for nanoparticle margination and physiology based pharmacokinetics.Computers & chemical engineering · 2025Article
- Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome.Science advances · 2024Article
- Targeting vascular inflammation through emerging methods and drug carriers.Advanced drug delivery reviews · 2022Review
- Biophysical Considerations in the Rational Design and Cellular Targeting of Flexible Polymeric Nanoparticles.Advanced materials interfaces · 2021Article
- Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery.Current opinion in structural biology · 2020Review
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- Stiffness can mediate balance between hydrodynamic forces and avidity to impact the targeting of flexible polymeric nanoparticles in flow.Nanoscale · 2019Article
- Nanoparticle transport phenomena in confined flows.Advances in heat transfer · 2019Article
- Stochastic simulations of nanoparticle internalization through transferrin receptor dependent clathrin-mediated endocytosis.Biochimica et biophysica acta. General subjects · 2018Article
- Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.Biophysical journal · 2018Article
- Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier.PloS one · 2018Article
- Computational Models for Nanoscale Fluid Dynamics and Transport Inspired by Nonequilibrium Thermodynamics.Journal of heat transfer · 2017Article
- Thermodynamic free energy methods to investigate shape transitions in bilayer membranes.International journal of advances in engineering sciences and applied mathematics · 2016Article
- Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors.Royal Society open science · 2016Article
- Non-affinity factors modulating vascular targeting of nano- and microcarriers.Advanced drug delivery reviews · 2016Review
- Cell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles.Interface focus · 2016Article
- Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting.International journal of nanomedicine · 2016Article
- Hydrodynamic interactions of deformable polymeric nanocarriers and the effect of crosslinking.Soft matter · 2015Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We investigate the effects of particle size, shear flow, and resistance due to the glycocalyx on the multivalent binding of functionalized nanocarriers (NC) to endothelial cells (ECs). We address the much- debated issue of shear-enhanced binding by computing the binding free-energy landscapes of NC binding to the EC surface when the system is subjected to shear, using a model and simulation methodology based on the Metropolis Monte Carlo approach. The binding affinities calculated based on the free-energy profiles are found to be in excellent agreement with experimental measurements for different-sized NCs. The model suggests that increasing the size of NCs significantly increases the multivalency but only moderately enhances the binding affinities due to the entropy loss associated with bound receptors on the EC surface. A significant prediction of our model is that under flow conditions, the binding free energies of NCs are a nonmonotonic function of the shear force. They show a well-defined minimum at a critical shear value, and thus quantitatively mimic the shear-enhanced binding behavior observed in various experiments. More significantly, our results indicate that the interplay between multivalent binding and shear force can reproduce the shear-enhanced binding phenomenon, which suggests that under certain conditions, this phenomenon can also occur in systems that do not show a catch-bond behavior. In addition, the model also suggests that the impact of the glycocalyx thickness on NC binding affinity is exponential, implying a highly nonlinear effect of the glycocalyx on binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.