ArticleBiophysical journal2011
Substrate viscosity enhances correlation in epithelial sheet movement.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 0 citations in OpenAlex.
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- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture.Research square · 2025Article
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- Multiple particle tracking (MPT) using PEGylated nanoparticles reveals heterogeneity within murine lymph nodes and between lymph nodes at different locations.Biomaterials science · 2022Article
- Cells on Hydrogels with Micron-Scaled Stiffness Patterns Demonstrate Local Stiffness Sensing.Nanomaterials (Basel, Switzerland) · 2022Article
- Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity.Frontiers in cell and developmental biology · 2022Review
- "Viscotaxis"- directed migration of mesenchymal stem cells in response to loss modulus gradient.Acta biomaterialia · 2021Article
- Substrate Resistance to Traction Forces Controls Fibroblast Polarization.Biophysical journal · 2020Article
- The Cell Adaptation Time Sets a Minimum Length Scale for Patterned Substrates.Biophysical journal · 2020Article
- Stiffness Sensing by Cells.Physiological reviews · 2020Review
- Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction.Biomaterials · 2019Article
- Micropatterned substrates with physiological stiffness promote cell maturation and Pompe disease phenotype in human induced pluripotent stem cell-derived skeletal myocytes.Biotechnology and bioengineering · 2019Article
- Fibronectin fiber creep under constant force loading.Acta biomaterialia · 2019Article
- An Economic, Modular, and Portable Skin Viscoelasticity Measurement Device forMolecules (Basel, Switzerland) · 2019Article
- Wound Healing Coordinates Actin Architectures to Regulate Mechanical Work.Nature physics · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The movement of the epithelium plays vital roles in the development and renewal of complex tissues, from the separation of tissues in the early embryo, to turnover in the homeostasis of the gastrointestinal mucosa. Yet, despite its importance, a clear interpretation of the mechanism for collective motion in epithelial sheets remains elusive. This interpretation is prohibited by the lack of understanding of the relationship between motion and cell-cell contact, and their mediation by the mechanical properties of the underlying substrate. To better mimic physiological substrates that have inherent viscosity, we probe this relationship using polydimethylsiloxane, a substrate whose mechanical properties can be tuned from predominantly elastic to viscous by altering its cross-linking content. We therefore characterize the comparative spatiotemporal correlations in cell velocity during the movement of an epithelial monolayer as a function of the viscoelasticity of the substrate. Our results show that high correlation in cell velocity is achieved when the substrate G''(ω) is ~0.4 × G'(ω). This correlation is driven by a balance between cell-cell contact and the adhesion and contraction of the extracellular matrix. For G'(ω) > G'(ω), this balance shifts, and contraction of the tissue drives the substrate to flow, further elevating the correlation in movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.