ArticleBiophysical journal2011
Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Deriving a genetic regulatory network from an optimization principle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels.Developmental cell · 2023Article
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- Quantitative Comparison of the Anterior-Posterior Patterning System in the Embryos of FiveG3 (Bethesda, Md.) · 2019Article
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- Causality analysis detects the regulatory role of maternal effect genes in the earlyGenomics data · 2017Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Tissue patterning and cellular mechanics.The Journal of cell biology · 2015Review
- What does it take to evolve an enhancer? A simulation-based study of factors influencing the emergence of combinatorial regulation.Genome biology and evolution · 2015Article
- Quantitative analysis and modeling probe polarity establishment in C. elegans embryos.Biophysical journal · 2015Article
- A gene expression atlas of a bicoid-depleted Drosophila embryo reveals early canalization of cell fate.Development (Cambridge, England) · 2015Article
- Shadow enhancers enable Hunchback bifunctionality in the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mid-embryo patterning and precision in Drosophila segmentation: Krüppel dual regulation of hunchback.PloS one · 2015Article
- Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos.PeerJ · 2015Article
- Making models match measurements: model optimization for morphogen patterning networks.Seminars in cell & developmental biology · 2014Review
- The embryo as a laboratory: quantifying transcription in Drosophila.Trends in genetics : TIG · 2014Review
- Evolutionary Design of Gene Networks: Forced Evolution by Genomic Parasites.Parallel processing letters · 2014Article
- Article
- Using evolutionary computations to understand the design and evolution of gene and cell regulatory networks.Methods (San Diego, Calif.) · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Segmentation of the Drosophila melanogaster embryo results from the dynamic establishment of spatial mRNA and protein patterns. Here, we exploit recent temporal mRNA and protein expression measurements on the full surface of the blastoderm to calibrate a dynamical model of the gap gene network on the entire embryo cortex. We model the early mRNA and protein dynamics of the gap genes hunchback, Kruppel, giant, and knirps, taking as regulatory inputs the maternal Bicoid and Caudal gradients, plus the zygotic Tailless and Huckebein proteins. The model captures the expression patterns faithfully, and its predictions are assessed from gap gene mutants. The inferred network shows an architecture based on reciprocal repression between gap genes that can stably pattern the embryo on a realistic geometry but requires complex regulations such as those involving the Hunchback monomer and dimers. Sensitivity analysis identifies the posterior domain of giant as among the most fragile features of an otherwise robust network, and hints at redundant regulations by Bicoid and Hunchback, possibly reflecting recent evolutionary changes in the gap-gene network in insects.
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