ArticleNutrition journal2011
Determinants of selenium status in healthy adults.
Article in Nutrition journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Vitamin Metabolism and Its Dependency on Genetic Variations Among Healthy Adults: A Systematic Review for Precision Nutrition Strategies.Nutrients · 2025Pooled it
- The association between blood selenium and metabolic syndrome in adults: a systematic review and dose-response meta-analysis of epidemiologic studies.Frontiers in nutrition · 2024Pooled it
- Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.Nutrients · 2014Pooled it
- Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.The American journal of clinical nutrition · 2016Trial
- Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults.The Journal of nutrition · 2015Trial
- Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial.Cancer prevention research (Philadelphia, Pa.) · 2014Trial
- Current Advances in the Physiological Roles of the Thioredoxin-Like Family of Selenoproteins.Biological trace element research · 2026Review
- The Role of Se-Containing Glutathione Peroxidases and Thioredoxin Reductases in Oncogenesis: Expression Paradoxes and Therapeutic Prospects.Antioxidants (Basel, Switzerland) · 2026Review
- Selenium Nanoparticles: Synthesis, Stability and In Vitro Evaluation in Human Lens Epithelial Cells.Pharmaceutics · 2025Article
- Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation.Biomolecules · 2025Review
- Selenium compounds for cancer prevention and therapy - human clinical trial considerations.Medical review (2021) · 2025Review
- Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status.Frontiers in nutrition · 2024Article
- Impact of dietary selenium and blood concentration on liver function: a population-based study.Frontiers in nutrition · 2024Article
- Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6-59 months in rural Zimbabwe.PLOS global public health · 2024Article
- Correlation between dietary selenium intake and stroke in the National Health and Nutrition Examination Survey 2003-2018.Annals of medicine · 2022Article
- Selenium status and type 2 diabetes risk.Archives of biochemistry and biophysics · 2022Review
- Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?Biological trace element research · 2021Review
- Trace Element Analysis in Whole Blood and Plasma for Reference Levels in a Selected Queensland Population, Australia.International journal of environmental research and public health · 2021Article
- Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine.Frontiers in endocrinology · 2021Article
- Se Status Prediction by Food Intake as Compared to Circulating Biomarkers in a West Algerian Population.Nutrients · 2020Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenium (Se) status in non-deficient subjects is typically assessed by the Se contents of plasma/serum. That pool comprises two functional, specific selenoprotein components and at least one non-functional, non-specific components which respond differently to changes in Se intake. A more informative means of characterizing Se status in non-deficient individuals is needed.
methodsMultiple biomarkers of Se status (plasma Se, serum selenoprotein P [SEPP1], plasma glutathione peroxidase activity [GPX3], buccal cell Se, urinary Se) were evaluated in relation to selenoprotein genotypes (GPX1, GPX3, SEPP1, SEP15), dietary Se intake, and parameters of single-carbon metabolism in a cohort of healthy, non-Se-deficient men (n = 106) and women (n = 155).
conclusionsPlasma Se concentration was 142.0 ± 23.5 ng/ml, with GPX3 and serum-derived SEPP1 calculated to comprise 20% and 34%, respectively, of that total. The balance, comprised of non-specific components, accounted for virtually all of the interindividual variation in total plasma Se. Buccal cell Se was associated with age and plasma homocysteine (hCys), but not plasma Se. SEPP1 showed a quadratic relationship with body mass index, peaking at BMI 25-30. Urinary Se was greater in women than men, and was associated with metabolic body weight (kg0.75), plasma folate, vitamin B12 and hCys (negatively). One GPX1 genotype (679T/T) was associated with significantly lower plasma Se levels than other allelic variants. Selenium intake, estimated from food frequency questionnaires, did not predict Se status as indicated by any biomarker. These results show that genotype, methyl-group status and BMI contribute to variation in Se biomarkers in Se-adequate individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.