ArticleBMC evolutionary biology2011
Evidence for a high mutation rate at rapidly evolving yeast centromeres.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Towards a unified model of aneuploid karyotype dynamics.PLoS genetics · 2026Article
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- Genetic diversity and evolution of rice centromeres.Nature genetics · 2025Article
- Independent evolution of holocentric chromosomes in an early branching apicomplexan parasite.bioRxiv : the preprint server for biology · 2025Article
- Footprints of Human Migration in the Population Structure of Wild Baker's Yeast.Molecular ecology · 2025Article
- On the rate of aneuploidy reversion in a wild yeast model.Genetics · 2025Article
- Splitting the yeast centromere by recombination.Nucleic acids research · 2024Article
- Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence.Molecular cell · 2023Article
- Recent insights into the evolution of mutation rates in yeast.Current opinion in genetics & development · 2022Review
- The genetics and epigenetics of satellite centromeres.Genome research · 2022Article
- tRNAs as a Driving Force of Genome Evolution in Yeast.Frontiers in microbiology · 2021Review
- Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- High-resolution mapping of the recombination landscape of the phytopathogen Fusarium graminearum suggests two-speed genome evolution.Molecular plant pathology · 2018Article
- Evolutionary biology through the lens of budding yeast comparative genomics.Nature reviews. Genetics · 2017Review
- Habitat Predicts Levels of Genetic Admixture inG3 (Bethesda, Md.) · 2017Article
- CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model.Scientific reports · 2016Article
- Centromeres of the Yeast Komagataella phaffii (Pichia pastoris) Have a Simple Inverted-Repeat Structure.Genome biology and evolution · 2016Article
- Summer temperature can predict the distribution of wild yeast populations.Ecology and evolution · 2016Article
- Atypical centromeres in plants-what they can tell us.Frontiers in plant science · 2015Review
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough their role in cell division is essential, centromeres evolve rapidly in animals, plants and yeasts. Unlike the complex centromeres of plants and aminals, the point centromeres of Saccharomcyes yeasts can be readily sequenced to distinguish amongst the possible explanations for fast centromere evolution.
resultsUsing DNA sequences of all 16 centromeres from 34 strains of Saccharomyces cerevisiae and population genomic data from Saccharomyces paradoxus, I show that centromeres in both species evolve 3 times more rapidly even than selectively unconstrained DNA. Exceptionally high levels of polymorphism seen in multiple yeast populations suggest that rapid centromere evolution does not result from the repeated selective sweeps expected under meiotic drive. I further show that there is little evidence for crossing-over or gene conversion within centromeres, although there is clear evidence for recombination in their immediate vicinity. Finally I show that the mutation spectrum at centromeres is consistent with the pattern of spontaneous mutation elsewhere in the genome.
conclusionsThese results indicate that rapid centromere evolution is a common phenomenon in yeast species. Furthermore, these results suggest that rapid centromere evolution does not result from the mutagenic effect of gene conversion, but from a generalised increase in the mutation rate, perhaps arising from the unusual chromatin structure at centromeres in yeast and other eukaryotes.
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