ArticleRetrovirology2011
Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface.
Article in Retrovirology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- The Three Pioneers in the Discovery of the Human Immunodeficiency Virus.Infectious diseases & clinical microbiology · 2025Article
- Host-Viral Interactions at the Maternal-Fetal Interface. What We Know and What We Need to Know.Frontiers · 2022Article
- Preterm Birth in Women With HIV: The Role of the Placenta.Frontiers in global women's health · 2022Review
- Decidua Basalis: An Ex Vivo Model to Study HIV-1 Infection During Pregnancy and Beyond.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Pediatric HIV-1 Acquisition and Lifelong Consequences of Infant Infection.Current immunology reviews · 2019Article
- NK cells control HIV-1 infection of macrophages through soluble factors and cellular contacts in the human decidua.Retrovirology · 2016Article
- The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication.Mucosal immunology · 2016Article
- The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.Cellular & molecular immunology · 2016Article
- Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.Journal of virology · 2015Article
- The up side of decidual natural killer cells: new developments in immunology of pregnancy.Immunology · 2014Review
- Human decidual macrophages and NK cells differentially express Toll-like receptors and display distinct cytokine profiles upon TLR stimulation.Frontiers in microbiology · 2014Article
- T cell behavior at the maternal-fetal interface.The International journal of developmental biology · 2014Review
- Human decidual NK cells: unique and tightly regulated effector functions in healthy and pathogen-infected pregnancies.Frontiers in immunology · 2013Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.Science (New York, N.Y.) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternofetal transmission (MFT) of HIV-1 is relatively rare during the first trimester of pregnancy despite the permissivity of placental cells for cell-to-cell HIV-1 infection. Invasive placental cells interact directly with decidual cells of the uterine mucosa during the first months of pregnancy, but the role of the decidua in the control of HIV-1 transmission is unknown.
resultsWe found that decidual mononuclear cells naturally produce low levels of IL-10, IL-12, IL-15, TNF-α, IFN-α, IFN-γ and CXCL-12 (SDF-1), and large amounts of CCL-2 (MCP1), CCL-3 (MIP-1α), CCL-4 (MIP-1β), CCL-5 (Rantes), CXCL-10 (IP-10), IL-6 and IL-8. CCL-3 and CCL-4 levels were significantly upregulated by in vitro infection with R5 HIV-1 but not X4. Decidual CD14+ antigen presenting cells were the main CCL-3 and CCL-4 producers among decidual leukocytes. R5 and X4 HIV-1 infection was inhibited by decidual cell culture supernatants in vitro. Using HIV-1 pseudotypes, we found that inhibition of the HIV-1 entry step was inhibited by decidual soluble factors.
conclusionOur findings show that decidual innate immunity (soluble factors) is involved in the control of HIV-1 infection at the maternofetal interface. The decidua could thus serve as a mucosal model for identifying correlates of protection against HIV-1 infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.