ReviewIUBMB life2011
Effects of ethanol on physiological retinoic acid levels.
Review in IUBMB life, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Retinoids in the Pathogenesis and Treatment of Liver Diseases.Nutrients · 2022Review
- Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment.Environmental research · 2021Article
- Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol-Induced Craniofacial Defects.Alcoholism, clinical and experimental research · 2020Article
- Review
- Animal models of gene-alcohol interactions.Birth defects research · 2020Review
- Modification of stem cell states by alcohol and acetaldehyde.Chemico-biological interactions · 2020Review
- Post-natal all-trans-retinoic acid biosynthesis.Methods in enzymology · 2020Article
- Diving into the world of alcohol teratogenesis: a review of zebrafish models of fetal alcohol spectrum disorder.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2018Review
- Review
- Gene-environment interactions in development and disease.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis.Zebrafish · 2016Review
- Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia.Investigative ophthalmology & visual science · 2016Article
- Role of microRNAs in Alcohol-Induced Multi-Organ Injury.Biomolecules · 2015Review
- Alcohol exposure in utero perturbs retinoid homeostasis in adult rats.Hepatobiliary surgery and nutrition · 2015Article
- Leukocyte homing, fate, and function are controlled by retinoic acid.Physiological reviews · 2015Review
- Maternal periconceptional alcohol consumption and congenital limb deficiencies.Birth defects research. Part A, Clinical and molecular teratology · 2014Article
- Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes.Alcoholism, clinical and experimental research · 2014Article
- The adverse effects of alcohol on vitamin A metabolism.Nutrients · 2012Review
- Functions of Intracellular Retinoid Binding-Proteins.Sub-cellular biochemistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
All-trans-retinoic acid (atRA) serves essential functions during embryogenesis and throughout postnatal vertebrate life. Insufficient or excess atRA causes teratogenic and/or toxic effects in the developing embryo: interference with atRA biosynthesis or signaling likely underlies some forms of cancer. Many symptoms of vitamin A (atRA precursor) deficiency and/or toxicity overlap with those of another pleiotropic agent--ethanol. These overlapping symptoms have prompted research to understand whether interference with atRA biosynthesis and/or action may explain (in part) pathology associated with excess ethanol consumption. Ethanol affects many aspects of retinoid metabolism and mechanisms of action site specifically, but no robust data support inhibition of vitamin A metabolism, resulting in decreased atRA in vivo during normal vitamin A nutriture. Actually, ethanol either has no effect on or increases atRA at select sites. Despite this realization, insight into whether interactions between ethanol and retinoids represent cause versus effect requires additional research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.