Evidence map›Paper›PMID 21766221›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2011

Progression of new onset to established persistent atrial fibrillation: an implantable device-based analysis with implications for clinical classification of persistent atrial fibrillation.

Rangadham Nagarakanti, Sanjeev Saksena, Douglas Hettrick, Jodi L Koehler, Andrea Grammatico, Luigi Padeletti

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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Atrial Fibrillation can adversely impact Heart Failure with Preserved Ejection Fraction by its association with Heart Failure Progression and Mortality: A Post-Hoc Propensity Score-Matched Analysis of the TOPCAT Americas Trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  2. Heart failure progression and mortality in atrial fibrillation patients with preserved or reduced left ventricular ejection fraction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019
    Article
  3. Article
  4. The natural history of atrial fibrillation in patients with permanent pacemakers: is atrial fibrillation a progressive disease?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015
    Article
  5. Review
  6. Clinical trials of antiarrhythmic therapies and optimizing health care resource deployment: the need for a paradigm shift.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2012
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Rangadham NagarakantiElectrophysiology Research Foundation, 161 Washington Valley Road, Suite 201, Warren, NJ 07059, USA.
Sanjeev Saksena
Douglas Hettrick
Jodi L Koehler
Andrea Grammatico
Luigi Padeletti
Electrophysiology Research Foundation · USMedtronic (United States) · USMedtronic (Italy) · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe temporal patterns of onset of persistent atrial fibrillation (AF) recurrences leading to established persistent AF is currently unknown.

methodsThree hundred thirty patients with a history of paroxysmal AF and bradycardia (mean age, 70 ± 10 years; 61% male) with implanted pacemakers that automatically recorded the cumulative daily atrial tachyarrhythmia (AT) burden were included in the analysis. Persistent AF was defined as device data showing ≥7 consecutive days with ≥23 h of AT. We analyzed the pattern and duration of persistent AF recurrences and time to each persistent AF episode recurrence.

resultsSeventy-eight patients (24%) developed their first persistent AT/AF after 147 ± 149 days. Follow up ranged from 14 to 499 days. Median AF burden in the week prior to persistent AF was 3.5 h/day. Fifty-four patients (16%) had a minimum of 180 days follow up after initial detection of persistent AF. Three of 54 patients (6%) immediately developed established AF; 32 of 51 patients (63%) returned to sinus rhythm but then had a second persistent AF event. These 32 patients had a minimum of 90 days follow up and 25 of these 32 patients (78 %) had a third persistent AF event. Time to recurrence analysis showed progressive abbreviation in persistent AF onset. The median durations of the first, second, and third persistent AF events were 16, 13, and 17 days, respectively.

conclusions(1) The time to first, second, and third persistent AF recurrences progressively decreases with a high likelihood of established persistent AF within 9 months of onset. (2) These data support intermittent but frequent AF monitoring for the detection of persistent AF recurrences to assess the efficacy of rhythm control interventions.

Indexed as

Pacemaker, ArtificialAgedAged, 80 and overAtrial FibrillationDisease ProgressionFemaleHumansMaleMonitoring, PhysiologicRecurrence

Identifiers

PMID21766221
OpenAlexW2049678988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.