ReviewNeural plasticity2011
Functional consequences of the disturbances in the GABA-mediated inhibition induced by injuries in the cerebral cortex.
Review in Neural plasticity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Differential Roles of Neuro-Inflammatory Regulator, MAPK11 in Cortex and Hippocampus Following Post-Stroke Cognitive Impairments in Rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.Frontiers in physiology · 2023Review
- GABAInternational journal of molecular sciences · 2022Article
- Review
- Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology.International journal of molecular sciences · 2019Review
- Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice.International journal of molecular sciences · 2019Article
- PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis.Neurochemical research · 2019Article
- Age-related differences in GABA levels are driven by bulk tissue changes.Human brain mapping · 2018Article
- Short Intracortical Inhibition During Voluntary Movement Reveals Persistent Impairment Post-stroke.Frontiers in neurology · 2018Article
- Histological Characterization of the Irritative Zones in Focal Cortical Dysplasia Using a Preclinical Rat Model.Frontiers in cellular neuroscience · 2018Article
- GABA alterations in pediatric sport concussion.Neurology · 2017Article
- Extrinsic and Intrinsic Brain Network Connectivity Maintains Cognition across the Lifespan Despite Accelerated Decay of Regional Brain Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Traumatic Brain Injury and Neuronal Functionality Changes in Sensory Cortex.Frontiers in systems neuroscience · 2016Review
- Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss.Frontiers in systems neuroscience · 2015Review
- Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?Neuroscience · 2014Review
- Focal cortical lesions induce bidirectional changes in the excitability of fast spiking and non fast spiking cortical interneurons.PloS one · 2014Article
- Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Shift from phasic to tonic GABAergic transmission following laser-lesions in the rat visual cortex.Pflugers Archiv : European journal of physiology · 2013Article
- Molecular mechanisms of cognitive dysfunction following traumatic brain injury.Frontiers in aging neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical injuries are often reported to induce a suppression of the intracortical GABAergic inhibition in the surviving, neighbouring neuronal networks. Since GABAergic transmission provides the main source of inhibition in the mammalian brain, this condition may lead to hyperexcitability and epileptiform activity of cortical networks. However, inhibition plays also a crucial role in limiting the plastic properties of neuronal circuits, and as a consequence, interventions aiming to reestablish a normal level of inhibition might constrain the plastic capacity of the cortical tissue. A promising strategy to minimize the deleterious consequences of a modified inhibitory transmission without preventing the potential beneficial effects on cortical plasticity may be to unravel distinct GABAergic signaling pathways separately mediating these positive and negative events. Here, gathering data from several recent studies, we provide new insights to better face with this "double coin" condition in the attempt to optimize the functional recovery of patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.