ArticleJournal of thyroid research2011
Thyroid hormone and cardiac disease: from basic concepts to clinical application.
Article in Journal of thyroid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02512978 (Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- HIF-1α-mediated mitochondrial autophagy in the post-treatment protective effect of thyroxine against myocardial ischemia-reperfusion injury.Journal of cardiothoracic surgery · 2026Article
- Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females.Endocrinology · 2026Article
- Thyroid disorders and cardiovascular manifestations: an update.Endocrine · 2022Review
- Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores.Scientific reports · 2021Article
- Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.Frontiers in physiology · 2021Review
- Novel uses of thyroid hormones in cardiovascular conditions.Endocrine · 2019Review
- The impact of thyroid hormone dysfunction on ischemic heart disease.Endocrine connections · 2019Review
- Post-myocardial infarction exercise training beneficially regulates thyroid hormone receptor isoforms.The journal of physiological sciences : JPS · 2018Article
- Thyroid hormones and cardiovascular disease.Nature reviews. Cardiology · 2017Review
- microRNA and thyroid hormone signaling in cardiac and skeletal muscle.Cell & bioscience · 2017Review
- Role of the Thyroid System in the Dynamic Complex Network of Cardioprotection.European cardiology · 2016Review
- Cardioprotection and thyroid hormones.Heart failure reviews · 2016Review
- MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.Journal of molecular endocrinology · 2016Article
- Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling.Molecular medicine (Cambridge, Mass.) · 2016Article
- Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.International journal of molecular sciences · 2015Review
- Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.Stem cell reports · 2014Article
- Changes in thyroid hormone receptors after permanent cerebral ischemia in male rats.Journal of molecular neuroscience : MN · 2014Article
- Thyroid hormone and cardiovascular system: from basic concepts to clinical application.Internal and emergency medicine · 2013Review
- Cell-type-dependent thyroid hormone effects on glioma tumor cell lines.Journal of thyroid research · 2011Article
- Revisiting the Thyroid-Heart Axis: Unravelling the Interplay of Hormones, Epigenomes and Precision Cardioprotection.Indian journal of endocrinology and metabolismReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature's models of regeneration provide substantial evidence that a natural healing process may exist in the heart. Analogies existing between the damaged myocardium and the developing heart strongly indicate that regulatory factors which drive embryonic heart development may also control aspects of heart regeneration. In this context, thyroid hormone (TH) which is critical in heart maturation during development appears to have a reparative role in adult life. Thus, changes in TH -thyroid hormone receptor (TR) homeostasis are shown to govern the return of the damaged myocardium to the fetal phenotype. Accordingly, thyroid hormone treatment preferentially rebuilds the injured myocardium by reactivating developmental gene programming. Clinical data provide further support to this experimental evidence and changes in TH levels and in particular a reduction of biologically active triiodothyronine (T3) in plasma after myocardial infarction or during evolution of heart failure, are strongly correlated with patients morbidity and mortality. The potential of TH to regenerate a diseased heart has now been testing in patients with acute myocardial infarction in a phase II, randomized, double blind, placebo-controlled study (the THiRST study).
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.