ArticleTherapeutic advances in neurological disorders2011
Current approaches to the treatment of paraneoplastic encephalitis.
Article in Therapeutic advances in neurological disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2024Pooled it
- Anti-Ri Paraneoplastic Neurological Syndrome Presenting with Ocular Flutter in a Patient with Breast Cancer.Brain sciences · 2025Article
- A Rapid Review of Adenocarcinoma and Pulmonary Tumor Thrombotic Microangiopathy: A Deadly Duo.Cureus · 2025Review
- Paraneoplastic neurological syndromes of small cell lung cancer.Postepy psychiatrii neurologii · 2024Review
- Anti-Ri paraneoplastic neurological syndrome presenting with bilateral cranial nerve VI palsy and jaw dystonia-a distinctive syndrome within the anti-Ri spectrum? : Case report and literature review.Wiener medizinische Wochenschrift (1946) · 2024Review
- SOX-1 antibodies in a patient with Crohn's disease: a case report.BMC neurology · 2022Article
- Article
- Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study.Annals of clinical and translational neurology · 2022Observational
- Paraneoplastic neurological syndrome: an evolving story.Neuro-oncology practice · 2021Review
- Rare paraneoplastic syndrome of prostatic cancer: limbic encephalitis: a case report.Journal of medical case reports · 2021Article
- Neurological paraneoplastic syndrome caused by small cell lung cancer: a case report.Translational cancer research · 2020Article
- Recommendations for cerebrospinal fluid analysis.Folia microbiologica · 2019Review
- Article
- Paraneoplastic limbic encephalitis associated with lung cancer.Scientific reports · 2018Article
- Gastaut-Geschwind Syndrome, Faciobrachial Dystonic Seizure, and Autoimmune Limbic Encephalitis.Case reports in psychiatry · 2018Article
- Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma.Case reports in hematology · 2018Article
- Diagnostics of paraneoplastic neurological syndromes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Review
- Myoclonic Disorders.Brain sciences · 2017Review
- Added diagnostic utility of PET in a patient with subacute encephalopathy and small-cell lung cancer.Lung cancer management · 2017Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraneoplastic neurological syndromes (PNSs) cover a wide range of diseases and involve both the central nervous system (CNS) and peripheral nervous system. Paraneoplastic encephalitis comprises several diseases such as paraneoplastic cerebellar degeneration (PCD), limbic encephalitis (LE), paraneoplastic encephalomyelitis (PEM), brainstem encephalitis, opsomyoclonus syndrome, in addition to other even less frequently occurring entities. LE was the first historically identified CNS PNS, and similarities between other temporal lobe diseases such as herpes encephalitis have been elucidated. In the past few decades several autoantibodies have been described in association with LE. These encompass the classical 'onconeuronal' antibodies (abs) such as Hu, Yo, Ri and others, and now additionally abs towards either ion channels or surface antigens. The clinical core findings in LE are various mental changes such as amnesia or confusion, often associated with seizures. Careful characterization of psychiatric manifestations and/or associated neurological signs can help to characterize the syndrome and type of ab. The treatment options in LE depend on the aetiology. In LE caused by onconeuronal abs, the treatment options are poor. In two types of abs associated with LE, abs against ion channels and surface antigens (e.g. NMDA), immunomodulatory treatments seem effective, making these types of LE treatable conditions. However, LE can also occur without being associated with cancer, in which case only immunomodulation is required. Despite effective treatments, some patients' residual deficits remain, and recurrences have also been described.
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