ArticleCurrent gerontology and geriatrics research2011
Age-related changes in the hepatic pharmacology and toxicology of paracetamol.
Article in Current gerontology and geriatrics research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- "Too Much of a Good Thing": Inadvertent Acetaminophen Overdose in a Low-Weight Elderly Patient.Clinical case reports · 2025Article
- Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain.Pain and therapy · 2024Article
- The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria.International journal of molecular sciences · 2022Article
- Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury.NPJ systems biology and applications · 2022Article
- Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis.Drugs & aging · 2022Article
- Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice.International journal of hepatology · 2020Article
- Testosterone propionate activated the Nrf2-ARE pathway in ageing rats and ameliorated the age-related changes in liver.Scientific reports · 2019Article
- Paracetamol in Older People: Towards Evidence-Based Dosing?Drugs & aging · 2018Review
- Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.BioMed research international · 2017Review
- The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.Fundamental & clinical pharmacology · 2016Article
- Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.Experimental gerontology · 2016Article
- Age-Related Changes in Hepatic Function: An Update on Implications for Drug Therapy.Drugs & aging · 2015Review
- [Drug interactions in pain therapy].Schmerz (Berlin, Germany) · 2015Review
- Effects of food on pharmacokinetics of immediate release oral formulations of simple analgesics: potential implications for drug use, safety and efficacy.British journal of clinical pharmacology · 2015Article
- [Non-opioid pain medication in the elderly].Schmerz (Berlin, Germany) · 2015Review
- Pain in the Frail or Elderly Patient: Does Tapentadol Have a Role?Drugs & aging · 2015Review
- Age-related loss of responsiveness to 2,5-dimethoxy-4-iodoamphetamine in liver sinusoidal endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations.Computational and structural biotechnology journal · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.