Evidence map›Paper›PMID 21765648›Full record

ArticleInternational journal of mass spectrometry2011

Mass spectrometric based analysis, characterization and applications of circulating cell free DNA isolated from human body fluids.

Vaneet K Sharma, Paul Vouros, James Glick

Registry-linked trialAbstract read
In one paragraph

Article in International journal of mass spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02988544 (Artificial Shrinkage of Fresh Blastocyst), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02988544 nacompletednot on this mapstarted 2018, after this paper: background citation

Artificial Shrinkage of Fresh Blastocyst: Impact on Success Rates in Assisted Reproductive Technology

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2018 to 2022Enrolled150ConditionsInfertility Assisted Reproductive TechnologyArmsArtificial shrinkage
3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The utility of cfDNA in TGCT patient management: a systematic review.Therapeutic advances in medical oncology · 2022
    Review
  6. Review
  7. Review
  8. Characterizing the Cancer Genome in Blood.Cold Spring Harbor perspectives in medicine · 2019
    Review
  9. Article
  10. Recent technical and biological development in the analysis of biomarker N-deoxyguanosine-C8-4-aminobiphenyl.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2018
    Review
  11. Review
  12. Article
  13. Review
  14. Observational
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vaneet K SharmaDepartment of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, Massachusetts 02115.
Paul Vouros
James Glick

Funding

LC-MS Analysis of DNA Adducts of Aromatic Amines: Relationship to Bladder CancerR01CA069390 · NCI · NORTHEASTERN UNIVERSITY · PI VOUROS, PAUL · 1996 to 2013
$2.7M
Relating DNA Adducts and ToxicogenomicsR01CA112231 · NCI · NORTHEASTERN UNIVERSITY · PI VOUROS, PAUL · 2005 to 2009
$2.2M
NCI NIH HHS R01 CA069390NCI NIH HHS R01 CA112231
6 · The paper itself

Abstract

In the past decade, cell free DNA, or circulating cell free DNA, or cell free circulating DNA, isolated from body fluids such as plasma/serum/urine has emerged as an important tool for clinical diagnostics. The molecular biology of circulating cell free DNA is poorly understood but there is currently an increased effort to understand the origin, mechanism of its circulation, and sensitive characterization for the development of diagnostic applications. There has been considerable progress towards these goals using real time polymerase chain reaction technique (rt-PCR). More recently, new attempts to incorporate mass spectrometric techniques to develop accurate and highly sensitive high-throughput clinical diagnostic tests have been reported. This review focuses on the methods to isolate circulating cell free DNA from body fluids, their quantitative analysis and mass spectrometry based characterization in evolving applications as prenatal and cancer diagnostic tools.

Identifiers

PMID21765648
PMCPMC3134299

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.