ArticleJournal of biomedicine & biotechnology2011
Identification of NF-κB modulation capabilities within human intestinal commensal bacteria.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
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- Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice.Journal of microbiology and biotechnology · 2025Article
- Changes in gut microbiota predict neutropenia after induction treatment in childhood acute lymphoblastic leukemia.Blood advances · 2025Article
- Interplay between the abdominopelvic radiotherapy and gut microbiota.Frontiers in microbiology · 2025Review
- The Role of Microbiome and Probiotics in Chemo-Radiotherapy-Induced Diarrhea: A Narrative Review of the Current Evidence.Cancer reports (Hoboken, N.J.) · 2024Review
- Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease.Brain sciences · 2024Review
- Mucositis and Infection in Hematology Patients.International journal of molecular sciences · 2023Article
- Cytomegalovirus infection disrupts the influence of short-chain fatty acid producers on Treg/Th17 balance.Microbiome · 2022Article
- Tributyrin administration improves intestinal development and health in pre-weaned dairy calves fed milk replacer.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Bacteroides muris sp. nov. isolated from the cecum of wild-derived house mice.Archives of microbiology · 2022Article
- Butyrate Ameliorates Intestinal Epithelial Barrier Injury Via Enhancing Foxp3+ Regulatory T-Cell Function in Severe Acute Pancreatitis Model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Gut microbiota diversity and specific composition during immunotherapy in responders with non-small cell lung cancer.Frontiers in molecular biosciences · 2022Article
- Molecular and Cellular Mechanisms Influenced by Postbiotics.International journal of molecular sciences · 2021Review
- A Link between Chronic Kidney Disease and Gut Microbiota in Immunological and Nutritional Aspects.Nutrients · 2021Review
- Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice.Scientific reports · 2021Article
- The Impact of Gut Microbiota on Radiation-Induced Enteritis.Frontiers in cellular and infection microbiology · 2021Review
- Exploring the Triple Interaction between the Host Genome, the Epigenome, and the Gut Microbiome in Type 1 Diabetes.International journal of molecular sciences · 2020Review
- Butyrate mediates anti-inflammatory effects ofGut microbes · 2020Article
- Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal microbiota plays an important role in modulation of mucosal immune responses. To seek interactions between intestinal epithelial cells (IEC) and commensal bacteria, we screened 49 commensal strains for their capacity to modulate NF-κB. We used HT-29/kb-seap-25 and Caco-2/kb-seap-7 intestinal epithelial cells and monocyte-like THP-1 blue reporter cells to measure effects of commensal bacteria on cellular expression of a reporter system for NF-κB. Bacteria conditioned media (CM) were tested alone or together with an activator of NF-κB to explore its inhibitory potentials. CM from 8 or 10 different commensal species activated NF-κB expression on HT-29 and Caco-2 cells, respectively. On THP-1, CM from all but 5 commensal strains stimulated NF-κB. Upon challenge with TNF-α or IL-1β, some CM prevented induced NF-κB activation, whereas others enhanced it. Interestingly, the enhancing effect of some CM was correlated with the presence of butyrate and propionate. Characterization of the effects of the identified bacteria and their implications in human health awaits further investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.