ArticleMediators of inflammation2011
Impact of short-term systemic hypoxia on phagocytosis, cytokine production, and transcription factor activation in peripheral blood cells.
Article in Mediators of inflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Low hypoxia tolerance as a determinant of the proinflammatory phenotype: a trained immunity perspective.Frontiers in immunology · 2026Review
- Article
- The known and unknown of post-pump chorea: a case report on robust steroid responsiveness implicating occult neuroinflammation.Frontiers in immunology · 2024Article
- The acute leukocyte and cytokine response of older adults to resistance exercise in normobaric hypoxia.Biology of sport · 2023Article
- An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices.Antioxidants (Basel, Switzerland) · 2023Article
- The emerging role for metabolism in fueling neutrophilic inflammation.Immunological reviews · 2023Review
- Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia.Pediatric research · 2023Article
- Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments.Cell metabolism · 2023Article
- Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review.Frontiers in immunology · 2022Review
- The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude.Nutrients · 2020Review
- The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils andInternational journal of molecular sciences · 2019Review
- Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds.The Journal of surgical research · 2019Observational
- Transcatheter valve-in-valve implantation (VinV-TAVR) for failed surgical aortic bioprosthetic valves.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay.Journal of visualized experiments : JoVE · 2016Article
- Immunologic Consequences of Hypoxia during Critical Illness.Anesthesiology · 2016Article
- Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis.Mucosal immunology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia frequently associated with certain physiologic and pathologic conditions influences numerous cellular functions. Because the effects of short-term hypoxia are incompletely understood, we examined phagocytosis and cytokine production as well as the activation of the transcription factors HIF-1 and NFκB in peripheral blood cells of healthy volunteers exposed to an oxygen concentration equivalent to that found at a height of 5500 m. Furthermore, we analysed plasma HIF-1 and serum concentrations of various HIF-1-dependent genes. Results showed that short-term hypoxia increased phagocytosis in neutrophils without affecting monocyte phagocytosis. Hypoxia decreased basal TNFα concentration in monocytes and basal interferon γ concentration in CD4(+) T lymphocytes. In contrast, plasma HIF and serum VEGF concentrations were not affected by hypoxia, although serum EPO concentration was raised. In PBMC, hypoxia increased cytosolic HIF-1 concentration without affecting nuclear HIF-1 concentration and led to a rise in the nuclear NFκB in PBMC. Our results show that short-term hypoxia affects immune functions in healthy individuals. Furthermore, we speculate that the effects of hypoxia are not due to HIF-1, but are caused by the activation of NFκB .
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