ArticleDrugs of the future2009
PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.
Article in Drugs of the future, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?BMC neuroscience · 2014Trial
- Assessment of Treatment Efficacy in Patients with Chronic Tinnitus: An Ambispective Cohort Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Synthetic Methods of Quinoxaline Derivatives and their Potential Anti-inflammatory Properties.Mini reviews in medicinal chemistry · 2025Review
- Comparison of Tinnitus Handicap Inventory and Tinnitus Functional Index as Treatment Outcomes.Audiology research · 2022Article
- What's the buzz? The neuroscience and the treatment of tinnitus.Physiological reviews · 2021Review
- Tinnitus Update.Journal of clinical neurology (Seoul, Korea) · 2021Review
- Aberrant thalamocortical coherence in an animal model of tinnitus.Journal of neurophysiology · 2019Article
- Analysis of Factors Influencing the Efficiency of Acupuncture in Tinnitus Patients.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- The Role of MRI in Diagnosing Neurovascular Compression of the Cochlear Nerve Resulting in Typewriter Tinnitus.AJNR. American journal of neuroradiology · 2017Article
- Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial.International journal of preventive medicine · 2017Article
- Effect of Tianeptine on Depressed Tinnitus Patients.Journal of audiology & otology · 2016Article
- Sensorineural Tinnitus: Its Pathology and Probable Therapies.International journal of otolaryngology · 2016Review
- Is Hypozincemia Related to Tinnitus?: A Population Study Using Data From the Korea National Health and Nutrition Examination Survey.Clinical and experimental otorhinolaryngology · 2015Article
- Toward a Global Consensus on Outcome Measures for Clinical Trials in Tinnitus: Report From the First International Meeting of the COMiT Initiative, November 14, 2014, Amsterdam, The Netherlands.Trends in hearing · 2015Article
- Partial to complete suppression of unilateral noise-induced tinnitus in rats after cyclobenzaprine treatment.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- The Management and Outcomes of Pharmacological Treatments for Tinnitus.Current neuropharmacology · 2015Review
- Tinnitus-related changes in the inferior colliculus.Frontiers in neurology · 2015Review
- Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss.F1000Research · 2014Article
- Effects of furosemide on cochlear neural activity, central hyperactivity and behavioural tinnitus after cochlear trauma in guinea pig.PloS one · 2014Article
- State- and trait-related alterations of motor cortex excitability in tinnitus patients.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Subjective tinnitus, the phantom ringing or buzzing sensation that occurs in the absence of sound, affects 12-14% of adults; in some cases the tinnitus is so severe or disabling that patients seek medical treatment. However, although the economic and emotional impact of tinnitus is large, there are currently no FDA-approved drugs to treat this condition. Clinical trials are now underway to evaluate the efficacy of N-methyl-d-aspartate (NMDA) and dopamine D(2) antagonists, selective serotonin reuptake inhibitors (SSRIs), γ-aminobutyric acid (GABA) agonists and zinc dietary supplements. Previous off-label clinical studies, while not definitive, suggest that patients with severe depression may experience improvement in their tinnitus after treatment with antidepressants such as nortriptyline or sertraline. A small subpopulation of patients with what has been described as "typewriter tinnitus" have been shown to gain significant relief from the anticonvulsant carbamazepine. Preliminary studies with misoprostol, a synthetic prostaglandin E1 analogue, and sulpiride, a dopamine D(2) antagonist, have shown promise. Animal behavioral studies suggest that GABA transaminase inhibitors and potassium channel modulators can suppress tinnitus. Additionally, improvements in tinnitus have also been noted in patients taking melatonin for significant sleep disturbances. Like other complex neurological disorders, one drug is unlikely to resolve tinnitus in all patients; therapies targeting specific subgroups are likely to yield the greatest success.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.