ReviewNature reviews. Genetics2011
The future of model organisms in human disease research.
Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 81 citations in OpenAlex.
- Special Issue "Using Model Organisms to Study Complex Human Diseases".International journal of molecular sciences · 2026Article
- A digital archive reveals how a funding agency cooperated with academics to support the nascent field of genomics.Nature communications · 2026Article
- Computational strategies for cross-species knowledge transfer.Nature methods · 2026Review
- Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Computational strategies for cross-species knowledge transfer and translational biomedicine.ArXiv · 2024Article
- Joint embedding of biological networks for cross-species functional alignment.Bioinformatics (Oxford, England) · 2023Article
- Universal chromatin state annotation of the mouse genome.Genome biology · 2023Article
- Review
- Contribution of model organism phenotypes to the computational identification of human disease genes.Disease models & mechanisms · 2022Article
- Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes.Nucleic acids research · 2022Article
- Experimental models of endocrine responsive breast cancer: strengths, limitations, and use.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- Ageing, metabolism and the intestine.EMBO reports · 2020Review
- Tollip Negatively Regulates Vascular Smooth Muscle Cell-Mediated Neointima Formation by Suppressing Akt-Dependent Signaling.Journal of the American Heart Association · 2018Article
- TISSUES 2.0: an integrative web resource on mammalian tissue expression.Database : the journal of biological databases and curation · 2018Article
- What Can We Learn About Human Disease from the Nematode C. elegans?Methods in molecular biology (Clifton, N.J.) · 2018Review
- Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information.Scientific reports · 2017Article
- Omics Data Complementarity Underlines Functional Cross-Communication in Yeast.Journal of integrative bioinformatics · 2017Article
- Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.Lipids in health and disease · 2016Article
- Network-Based Protein Biomarker Discovery Platforms.Genomics & informatics · 2016Review
- Network Modules of the Cross-Species Genotype-Phenotype Map Reflect the Clinical Severity of Human Diseases.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
Abstract
Model organisms have played a huge part in the history of studies of human genetic disease, both in identifying disease genes and characterizing their normal and abnormal functions. But is the importance of model organisms diminishing? The direct discovery of disease genes and variants in humans has been revolutionized, first by genome-wide association studies and now by whole-genome sequencing. Not only is it now much easier to directly identify potential disease genes in humans, but the genetic architecture that is being revealed in many cases is hard to replicate in model organisms. Furthermore, disease modelling can be done with increasing effectiveness using human cells. Where does this leave non-human models of disease?
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.