ArticleNature neuroscience2011
Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Gcm1 Orchestrates Lef1 Expression in Folate Deficiency-Induced Neural Tube Defects.Molecular neurobiology · 2025Article
- A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells.Stem cell research & therapy · 2025Article
- Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System.Stem cell reviews and reports · 2024Article
- Evolution of glial cells: a non-bilaterian perspective.Neural development · 2024Review
- Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function.Scientific reports · 2023Article
- Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii.International journal of clinical oncology · 2023Article
- Integrative analysis of DNA methylation and gene expression data for the diagnosis and underlying mechanism of Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins.Nature biotechnology · 2020Article
- Review
- The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Untangling Cortical Complexity During Development.Journal of experimental neuroscience · 2018Review
- Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.Cellular and molecular neurobiology · 2017Article
- TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.Genes & cancer · 2017Article
- The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation.Scientific reports · 2017Article
- Emerging mechanisms underlying astrogenesis in the developing mammalian brain.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- An evolutionary conserved interaction between the Gcm transcription factor and the SF1 nuclear receptor in the female reproductive system.Scientific reports · 2016Article
- The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation.Nature communications · 2016Article
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signaling mediated by Notch receptors is crucial for the development of many organs and the maintenance of various stem cell populations. The activation of Notch signaling is first detectable by the expression of an effector gene, Hes5, in the neuroepithelium of mouse embryos at embryonic day (E) 8.0-8.5, and this activation is indispensable for the generation of neural stem cells. However, the molecular mechanism by which Hes5 expression is initiated in stem-producing cells remains unknown. We found that mammalian Gcm1 and Gcm2 (glial cells missing 1 and 2) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication. Loss of both Gcm genes and subsequent lack of Hes5 upregulation in the neuroepithelium of E7.5-8.5 Gcm1(-/-); Gcm2(-/-) mice resulted in the impaired induction of neural stem cells. Our data suggest that Hes5 expression is serially activated first by Gcms and later by the canonical Notch pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.