ArticleNature nanotechnology2011
Cell-surface sensors for real-time probing of cellular environments.
Article in Nature nanotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 222 citations in OpenAlex.
- Toward point-of-care cancer diagnostics: gold nanoparticle-based colorimetric sensors.RSC advances · 2026Review
- Non-invasive detection of VEGF secretion from small clusters of mesenchymal stem cells using VEGF-SSSA integrated into the CellStudio platform.Mikrochimica acta · 2025Article
- Quantifying T cell receptor mechanics at membrane junctions using DNA origami tension sensors.Nature nanotechnology · 2024Article
- High-affinity one-step aptamer selection using a non-fouling porous hydrogel.Nature biotechnology · 2024Article
- The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring.International journal of molecular sciences · 2024Review
- Article
- Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting.Nature biomedical engineering · 2024Article
- Cell Surface Engineering Tools for Programming Living Assemblies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Advantages of Material Biofunctionalization Using Nucleic Acid Aptamers in Tissue Engineering and Regenerative Medicine.Molecular biotechnology · 2023Review
- A collagen-immobilized nanodevice forChemical science · 2023Article
- Multiplexed Detection of Molecular Interactions with DNA Origami Engineered Cells in 3D Collagen Matrices.ACS applied materials & interfaces · 2022Article
- Cell pairing for biological analysis in microfluidic devices.Biomicrofluidics · 2022Review
- Analysis of cell-nanoparticle interactions and imaging ofNanoscale advances · 2022Article
- DNA-Based Molecular Engineering of the Cell Membrane.Membranes · 2022Review
- Aptamers used for molecular imaging and theranostics - recent developments.Theranostics · 2022Review
- Synthetic nanosensors for imaging neuromodulators.Journal of neuroscience methods · 2021Review
- Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells.Nature communications · 2021Article
- Atomic Scale Interactions between RNA and DNA Aptamers with the TNF-BioMed research international · 2021Article
- Efficient and selective DNA modification on bacterial membranes.Chemical science · 2020Article
- Lipid-oligonucleotide conjugates for bioapplications.National science review · 2020Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 1 country.
Funding
Abstract
The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells with their environments in real time. Here, we show that a fluorescent sensor attached to a cell membrane can detect signalling molecules in the cellular environment. The sensor is an aptamer (a short length of single-stranded DNA) that binds to platelet-derived growth factor (PDGF) and contains a pair of fluorescent dyes. When bound to PDGF, the aptamer changes conformation and the dyes come closer to each other, producing a signal. The sensor, which is covalently attached to the membranes of mesenchymal stem cells, can quantitatively detect with high spatial and temporal resolution PDGF that is added in cell culture medium or secreted by neighbouring cells. The engineered stem cells retain their ability to find their way to the bone marrow and can be monitored in vivo at the single-cell level using intravital microscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.