ArticleThe EMBO journal2011
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- BEND6 promotes RNA viruses' replication by inhibiting innate immune responses.Science China. Life sciences · 2025Article
- A Drosophila model of mucopolysaccharidosis IIIB.Genetics · 2025Article
- DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations.Nucleic acids research · 2024Article
- MicroRNA mediated regulation of the onset of enteroblast differentiation in the Drosophila adult intestine.Cell reports · 2022Article
- BEND3 safeguards pluripotency by repressing differentiation-associated genes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes & development · 2022Article
- Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner.Biomedicines · 2020Article
- BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila.Nature communications · 2019Article
- Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive.Epigenetics & chromatin · 2019Article
- The BEN Domain Protein Insensitive Binds to theGenetics · 2018Article
- BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo.Scientific reports · 2016Article
- The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway.Cell division · 2016Review
- Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.BMC biology · 2015Article
- Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family.Genes & development · 2015Article
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Article
- CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.Development (Cambridge, England) · 2013Article
- BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.Development (Cambridge, England) · 2013Article
- The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors.Genes & development · 2013Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The Notch intracellular domain functions as a co-activator for the DNA-binding protein Suppressor of Hairless (Su(H)) to mediate myriad cell fate decisions. Notch pathway activity is balanced by transcriptional repression, mediated by Su(H) in concert with its Drosophila corepressor Hairless. We demonstrate that the Drosophila neural BEN-solo protein Insensitive (Insv) is a nuclear factor that inhibits Notch signalling during multiple peripheral nervous system cell fate decisions. Endogenous Insv was particularly critical when repressor activity of Su(H) was compromised. Reciprocally, ectopic Insv generated several Notch loss-of-function phenotypes, repressed most Notch targets in the E(spl)-C, and opposed Notch-mediated activation of an E(spl)m3-luc reporter. A direct role for Insv in transcriptional repression was indicated by binding of Insv to Su(H), and by strong chromatin immunoprecipitation of endogenous Insv to most E(spl)-C loci. Strikingly, ectopic Insv fully rescued sensory organ precursors in Hairless null clones, indicating that Insv can antagonize Notch independently of Hairless. These data shed first light on the in vivo function for a BEN-solo protein as an Su(H) corepressor in the Notch pathway regulating neural development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.