ArticleJournal of acquired immune deficiency syndromes (1999)2011
Willingness to participate in biomedical HIV prevention studies after the HVTN 503/Phambili trial: a survey conducted among adolescents in Soweto, South Africa.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Using surrogate vaccines to assess feasibility and acceptability of future HIV vaccine trials in men: a randomised trial in inner-city Johannesburg, South Africa.BMC public health · 2017Trial
- Uptake of genital mucosal sampling in HVTN 097, a phase 1b HIV vaccine trial in South Africa.PloS one · 2014Trial
- Parental waivers to enable adolescent participation in certain forms of health research: lessons from a South African case study.BMC medical ethics · 2022Article
- Gender and Power Dynamics of Social Relationships Shape Willingness to Participate in Biomedical HIV Prevention Research Among South African Adolescents and Young Adults.Frontiers in reproductive health · 2021Article
- Adolescent and Parent Perceptions about Participation in Biomedical Sexual Health Trials.Ethics & human research · 2020Article
- Six dimensions of research trial acceptability: how much, what, when, in what circumstances, to whom and why?Social science & medicine (1982) · 2018Article
- Psychosocial correlates of alcohol and other substance use among low-income adolescents in peri-urban Johannesburg, South Africa: A focus on gender differences.Journal of health psychology · 2017Article
- Prevalence, type, and correlates of trauma exposure among adolescent men and women in Soweto, South Africa: implications for HIV prevention.BMC public health · 2016Article
- Exposure to and experiences of violence among adolescents in lower socio-economic groups in Johannesburg, South Africa.BMC public health · 2015Article
- The HVTN503/Phambili HIV vaccine trial: a comparison of younger and older participants.International journal of STD & AIDS · 2014Article
- Article
- A qualitative analysis of factors influencing HPV vaccine uptake in Soweto, South Africa among adolescents and their caregivers.PloS one · 2013Article
- Inclusion of South African adolescents in HIV vaccine trials.Journal of AIDS and HIV research (Online) · 2012Article
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Authors and funding
6 authors.
Funding
Abstract
objectivesAdolescents may be appropriate for inclusion in biomedical HIV prevention trials. Adolescents' overall willingness to participate (WTP) in biomedical HIV prevention trials was examined, including after the prematurely discontinued phase IIb HVTN 503/Phambili HIV vaccine trial, in Soweto, South Africa.
methodsAn interview-administered cross-sectional survey was conducted among 506 adolescents (16-18 years) between October 2008 and March 2009. The assessment included WTP in HIV prevention trials, sexual and substance use behavior, and related psychosocial constructs. Multivariate logistic regression analyses examined predictors of WTP in biomedical prevention trials.
resultsThe sample primarily consisted of female participants (n = 298, 59%), and 50% of all participants were sexually active. WTP in general was high (93%), with 75% WTP in a vaccine trial after being informed about the HVTN 503/Phambili trial. Less exposure to stressors [odds ratio (OR): 2.8, confidence interval (CI): 1.3 to 6.3] was associated with adolescents' WTP in HIV biomedical prevention trials overall. Those with less exposure to stressors (OR: 1.7, CI: 1.1 to 2.8) and not sexually active (OR: 2.1, CI: 1.4 to 3.3) were predictive of WTP after the HVTN 503/Phambili trial. A higher number of sexual partners were associated with unwillingness to participate more generally (P = 0.039) and specifically after the HIV vaccine trial (P = 0.0004).
conclusionsThe high level of adolescents' WTP in biomedical prevention trials is encouraging, especially after the prematurely discontinued HVTN 503/Phambili HIV vaccine trial. High-risk youth were less likely to be WTP, although those not yet sexually active were more WTP. Future biomedical HIV prevention trials should address challenges to enrollment of high-risk adolescents who may show less WTP.
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