Evidence map›Paper›PMID 21765165›Full record

SynthesisSchizophrenia bulletin2013

Symptom domains and neurocognitive functioning can help differentiate social cognitive processes in schizophrenia: a meta-analysis.

Joseph Ventura, Rachel C Wood, Gerhard S Hellemann

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  17. International perspective on social cognition in schizophrenia: current stage and the next steps.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Review
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  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph VenturaDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California LosAngeles, Los Angeles, CA, USA. jventura@ucla.edu
Rachel C Wood
Gerhard S Hellemann

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2014
$18.6M
DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSR01MH037705 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 1985 to 2010
$5.1M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Hypothesis Web Development for Neuropsychiatric Phenomics (6 of 8)RL1LM009833 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARKER, DOUGLASS STOTT · 2007 to 2011
$1.5M
NIDCR NIH HHS UL1-DE019580NIMH NIH HHS MH37705NIMH NIH HHS P50 MH066286NIMH NIH HHS R21MH07391NLM NIH HHS RL1LM009833
6 · The paper itself

Abstract

backgroundThe existence of deficits in several social cognitive domains has been established in schizophrenia, and those impairments are known to be a significant determinant of functional outcome. Both symptoms and neurocognition have been linked to social cognitive deficits, but the nature and the relative strength of these relationships have not been established.

methodsA meta-analysis of 154 studies (combined N = 7175) was conducted to determine the magnitude of the relationships between 3 symptom domains (reality distortion, disorganization, and negative symptoms) and 6 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) domains of neurocognition with 4 domains of social cognition. Analyses were conducted to determine whether the strength of these relationships differed depending on the symptom type or neurocognitive domain under investigation.

resultsThe correlations between reality distortion and the domains of social cognition ranged from near zero to moderate (r's range from -.07 to -.22), as compared with the moderate association for disorganization (r's range from -.22 to -.32) and negative symptoms (r's range from -.20 to -.26). For each of the neurocognitive domains, the relationships to social cognitive domains were mostly moderate (r's range from .17 to .37), with no one neurocognitive domain being prominent.

conclusionsThe effect sizes of the correlations between disorganization and negative symptoms with social cognition were relatively larger and more consistent than reality distortion. The relationship between social cognition and 6 MATRICS domains of neurocognition were mostly moderate and relatively consistent. When considering disorganization and negative symptoms, the relationship to social cognitive processes was relatively as strong as for neurocognition.

Indexed as

Schizophrenic PsychologySocial PerceptionCognition DisordersHumansSchizophrenia

Identifiers

PMID21765165
PMCPMC3523911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.