ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis.Scientific reports · 2024Article
- Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets.Anatomy & cell biology · 2022Review
- Immune Privilege: The Microbiome and Uveitis.Frontiers in immunology · 2020Review
- Article
- T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.Scientific reports · 2018Article
- Ocular antigen does not cause disease unless presented in the context of inflammation.Scientific reports · 2017Article
- Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype.Investigative ophthalmology & visual science · 2015Article
- Macrophages and Uveitis in Experimental Animal Models.Mediators of inflammation · 2015Review
- Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis.Current molecular medicine · 2015Article
- MHC Class II Auto-Antigen Presentation is Unconventional.Frontiers in immunology · 2015Review
- Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.Nature communications · 2014Article
- Autoimmune and autoinflammatory mechanisms in uveitis.Seminars in immunopathology · 2014Review
- Updates on the risk markers and outcomes of severe juvenile idiopathic arthritis-associated uveitis.International journal of clinical rheumatology · 2013Article
- Effective Arrestin-Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis.Translational vision science & technology · 2013Article
- Interleukin-17 production and T helper 17 cells in peripheral blood mononuclear cells in response to ocular lysate in patients with birdshot chorioretinopathy.Molecular vision · 2013Article
- MHC class II tetramers.Journal of immunology (Baltimore, Md. : 1950) · 2012Review
- Interplay between innate and adaptive immunity in the development of non-infectious uveitis.Progress in retinal and eye research · 2012Review
- Role of dendritic cell subsets in immunity and their contribution to noninfectious uveitis.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
Noninfectious uveitis is a leading cause of blindness and thought to involve autoimmune T cell responses to retinal proteins (e.g., retinal arrestin [soluble-Ag (S-Ag)]). There are no known biomarkers for the disease. Susceptibility is associated with HLA, but little is known about susceptible class II alleles or the potentially pathogenic epitopes that they present. Using a humanized HLA-transgenic mouse model of S-Ag-induced autoimmune uveitis, we identified several susceptible and resistant alleles of HLA-DR and -DQ genes and defined pathogenic epitopes of S-Ag presented by the susceptible alleles. The sequences of these epitopes overlap with some previously identified peptides of S-Ag ("M" and "N"), known to elicit memory responses in lymphocytes of uveitis patients. HLA-DR-restricted, S-Ag-specific CD4(+) T cells could be detected in blood and draining lymph nodes of uveitic mice with HLA class II tetramers and transferred the disease to healthy mice. Importantly, tetramer-positive cells were detected in peripheral blood of a uveitis patient. To our knowledge, these findings provide the first tangible evidence that an autoimmune response to retina is causally involved in pathogenesis of human uveitis, demonstrating the feasibility of identifying and isolating retinal Ag-specific T cells from uveitis patients and may facilitate their development as biomarkers for the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.