ArticleApplied and environmental microbiology2011
Novel virulent and broad-host-range Erwinia amylovora bacteriophages reveal a high degree of mosaicism and a relationship to Enterobacteriaceae phages.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 114 citations in OpenAlex.
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- Beyond Antibiotics: Exploring the Potential of Bacteriophages and Phage Therapy.PHAGE (New Rochelle, N.Y.) · 2024Review
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- Genomic insights into novel Erwinia bacteriophages: unveiling their Henunavirus membership and host infection strategies.Current microbiology · 2024Article
- First EuropeanBiology · 2024Article
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- Broad-host-range lytic Erwinia phage Key with exopolysaccharide degrading activity.Virus research · 2023Article
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- Three Phages One Host: Isolation and Characterization ofInternational journal of molecular sciences · 2023Article
- Phage Cocktail in Combination with Kasugamycin as a Potential Treatment for Fire Blight Caused byAntibiotics (Basel, Switzerland) · 2022Article
- Isolation of Nine Bacteriophages Shown Effective against Erwinia amylovora in Korea.The plant pathology journal · 2022Article
- ICTV Virus Taxonomy Profile:The Journal of general virology · 2022Article
- NovelMicroorganisms · 2022Article
- Spontaneous Resistance ofFrontiers in microbiology · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A diverse set of 24 novel phages infecting the fire blight pathogen Erwinia amylovora was isolated from fruit production environments in Switzerland. Based on initial screening, four phages (L1, M7, S6, and Y2) with broad host ranges were selected for detailed characterization and genome sequencing. Phage L1 is a member of the Podoviridae, with a 39.3-kbp genome featuring invariable genome ends with direct terminal repeats. Phage S6, another podovirus, was also found to possess direct terminal repeats but has a larger genome (74.7 kbp), and the virus particle exhibits a complex tail fiber structure. Phages M7 and Y2 both belong to the Myoviridae family and feature long, contractile tails and genomes of 84.7 kbp (M7) and 56.6 kbp (Y2), respectively, with direct terminal repeats. The architecture of all four phage genomes is typical for tailed phages, i.e., organized into function-specific gene clusters. All four phages completely lack genes or functions associated with lysogeny control, which correlates well with their broad host ranges and indicates strictly lytic (virulent) lifestyles without the possibility for host lysogenization. Comparative genomics revealed that M7 is similar to E. amylovora virus ΦEa21-4, whereas L1, S6, and Y2 are unrelated to any other E. amylovora phage. Instead, they feature similarities to enterobacterial viruses T7, N4, and ΦEcoM-GJ1. In a series of laboratory experiments, we provide proof of concept that specific two-phage cocktails offer the potential for biocontrol of the pathogen.
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