ArticleJournal of bacteriology2011
Metabolomics reveals phospholipids as important nutrient sources during Salmonella growth in bile in vitro and in vivo.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Plasma metabonomics of classical swine fever virus-infected pigs.Frontiers in veterinary science · 2023Article
- Modulation of Host Lipid Pathways by Pathogenic Intracellular Bacteria.Pathogens (Basel, Switzerland) · 2020Review
- Development of Salmonellosis as Affected by Bioactive Food Compounds.Microorganisms · 2019Review
- Article
- Lipid Droplets: A Significant but Understudied Contributor of Host⁻Bacterial Interactions.Cells · 2019Review
- Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.Infection and immunity · 2018Article
- Sex Steroids Mediate Bidirectional Interactions Between Hosts and Microbes.Hormones and behavior · 2017Review
- Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts.Frontiers in medicine · 2017Review
- Article
- Stress responses in Streptococcus species and their effects on the host.Journal of microbiology (Seoul, Korea) · 2015Review
- Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes.Molecular bioSystems · 2013Article
- Metabolic signatures of triatomine vectors of Trypanosoma cruzi unveiled by metabolomics.PloS one · 2013Article
- Metabolic profiling for detection of Staphylococcus aureus infection and antibiotic resistance.PloS one · 2013Article
- Repression of Salmonella enterica phoP expression by small molecules from physiological bile.Journal of bacteriology · 2012Article
- The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets.Infection and immunity · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
During the colonization of hosts, bacterial pathogens are presented with many challenges that must be overcome for colonization to occur successfully. This requires the bacterial sensing of the surroundings and adaptation to the conditions encountered. One of the major impediments to the pathogen colonization of the mammalian gastrointestinal tract is the antibacterial action of bile. Salmonella enterica serovar Typhimurium has specific mechanisms involved in resistance to bile. Additionally, Salmonella can successfully multiply in bile, using it as a source of nutrients. This accomplishment is highly relevant to pathogenesis, as Salmonella colonizes the gallbladder of hosts, where it can be carried asymptomatically and promote further host spread and transmission. To gain insights into the mechanisms used by Salmonella to grow in bile, we studied the changes elicited by Salmonella in the chemical composition of bile during growth in vitro and in vivo through a metabolomics approach. Our data suggest that phospholipids are an important source of carbon and energy for Salmonella during growth in the laboratory as well as during gallbladder infections of mice. Further studies in this area will generate a better understanding of how Salmonella exploits this generally hostile environment for its own benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.